GO Annotations Graph

• Symbol: Slc30a8
• Name: solute carrier family 30 (zinc transporter), member 8
• ID: MGI:2442682

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0015297	antiporter activity	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0008324	monoatomic cation transmembrane transporter activity	IEA	J:72247
Molecular Function	GO:0042803	protein homodimerization activity	IPI	J:159443
Molecular Function	GO:0005385	zinc ion transmembrane transporter activity	ISO	J:164563
Molecular Function	GO:0005385	zinc ion transmembrane transporter activity	IBA	J:265628
Molecular Function	GO:0005385	zinc ion transmembrane transporter activity	IMP	J:154407
Molecular Function	GO:0005385	zinc ion transmembrane transporter activity	IMP	J:162163
Molecular Function	GO:0005385	zinc ion transmembrane transporter activity	IMP	J:153253
Molecular Function	GO:0140826	zinc:proton antiporter activity	ISO	J:164563
Cellular Component	GO:0031410	cytoplasmic vesicle	ISO	J:155856
Cellular Component	GO:0031410	cytoplasmic vesicle	IDA	J:159443
Cellular Component	GO:0000139	Golgi membrane	TAS	Reactome:R-MMU-216806
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0030141	secretory granule	ISO	J:164563
Cellular Component	GO:0030141	secretory granule	IDA	J:162163
Cellular Component	GO:0030667	secretory granule membrane	ISO	J:164563
Cellular Component	GO:0030667	secretory granule membrane	IDA	J:162163
Biological Process	GO:0030070	insulin processing	IMP	J:154407
Biological Process	GO:0030070	insulin processing	IMP	J:153253
Biological Process	GO:0030073	insulin secretion	ISO	J:155856
Biological Process	GO:0030073	insulin secretion	IMP	J:152629
Biological Process	GO:0030073	insulin secretion	ISO	J:164563
Biological Process	GO:0030073	insulin secretion	IBA	J:265628
Biological Process	GO:0006882	intracellular zinc ion homeostasis	ISO	J:155856
Biological Process	GO:0006882	intracellular zinc ion homeostasis	IMP	J:152629
Biological Process	GO:0006812	monoatomic cation transport	IEA	J:72247
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:60000
Biological Process	GO:0032024	positive regulation of insulin secretion	ISO	J:155856
Biological Process	GO:0061088	regulation of sequestering of zinc ion	ISO	J:155856
Biological Process	GO:0061088	regulation of sequestering of zinc ion	IBA	J:265628
Biological Process	GO:0060627	regulation of vesicle-mediated transport	ISO	J:155856
Biological Process	GO:0009749	response to glucose	ISO	J:155856
Biological Process	GO:0009749	response to glucose	IMP	J:152629
Biological Process	GO:0009749	response to glucose	ISO	J:164563
Biological Process	GO:0009749	response to glucose	IBA	J:265628
Biological Process	GO:0010043	response to zinc ion	IBA	J:265628
Biological Process	GO:0032119	sequestering of zinc ion	ISO	J:164563
Biological Process	GO:0055085	transmembrane transport	IEA	J:72247
Biological Process	GO:0062111	zinc ion import into organelle	ISO	J:164563
Biological Process	GO:0071577	zinc ion transmembrane transport	IBA	J:265628
Biological Process	GO:0006829	zinc ion transport	ISO	J:164563