GO Annotations Graph

• Symbol: Brip1
• Name: BRCA1 interacting protein C-terminal helicase 1
• ID: MGI:2442836

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0051539	4 iron, 4 sulfur cluster binding	IEA	J:60000
Molecular Function	GO:0043139	5'-3' DNA helicase activity	ISO	J:164563
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0003682	chromatin binding	ISO	J:155856
Molecular Function	GO:0003677	DNA binding	IEA	J:72247
Molecular Function	GO:0003678	DNA helicase activity	IBA	J:265628
Molecular Function	GO:0004386	helicase activity	IEA	J:72247
Molecular Function	GO:0004386	helicase activity	IEA	J:60000
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	IEA	J:72247
Molecular Function	GO:0051536	iron-sulfur cluster binding	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0003676	nucleic acid binding	IEA	J:72247
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0003724	RNA helicase activity	IEA	J:72245
Cellular Component	GO:0070532	BRCA1-B complex	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:73065
Cellular Component	GO:0031965	nuclear membrane	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	NAS	J:320080
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	ISO	J:73065
Biological Process	GO:0051026	chiasma assembly	IMP	J:227337
Biological Process	GO:0006974	DNA damage response	IEA	J:60000
Biological Process	GO:0006281	DNA repair	NAS	J:320080
Biological Process	GO:1990918	double-strand break repair involved in meiotic recombination	IBA	J:265628
Biological Process	GO:1990918	double-strand break repair involved in meiotic recombination	IMP	J:227337
Biological Process	GO:0007129	homologous chromosome pairing at meiosis	IMP	J:227337
Biological Process	GO:0035825	homologous recombination	NAS	J:320080
Biological Process	GO:0008584	male gonad development	IMP	J:227337
Biological Process	GO:0010705	meiotic DNA double-strand break processing involved in reciprocal meiotic recombination	IMP	J:227337
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:155856
Biological Process	GO:0006139	nucleobase-containing compound metabolic process	IEA	J:72247
Biological Process	GO:0006289	nucleotide-excision repair	IBA	J:265628
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	ISO	J:73065
Biological Process	GO:0072520	seminiferous tubule development	IMP	J:227337
Biological Process	GO:0007286	spermatid development	IMP	J:227337
Biological Process	GO:0007283	spermatogenesis	IMP	J:227337
Biological Process	GO:0007284	spermatogonial cell division	IMP	J:227337