GO Annotations Graph

• Symbol: Rigi
• Name: RNA sensor RIG-I
• ID: MGI:2442858

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0016887	ATP hydrolysis activity	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	IEA	J:72247
Molecular Function	GO:0003690	double-stranded DNA binding	IDA	J:145965
Molecular Function	GO:0003725	double-stranded RNA binding	IDA	J:182522
Molecular Function	GO:0003725	double-stranded RNA binding	ISO	J:164563
Molecular Function	GO:0003725	double-stranded RNA binding	IBA	J:265628
Molecular Function	GO:0003725	double-stranded RNA binding	IDA	J:186390
Molecular Function	GO:0005525	GTP binding	ISO	J:164563
Molecular Function	GO:0004386	helicase activity	IEA	J:60000
Molecular Function	GO:0016787	hydrolase activity	IEA	J:72247
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0140677	molecular function activator activity	ISO	J:164563
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0038187	pattern recognition receptor activity	ISO	J:164563
Molecular Function	GO:0038187	pattern recognition receptor activity	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:193456
Molecular Function	GO:0005515	protein binding	IPI	J:175771
Molecular Function	GO:0003723	RNA binding	IEA	J:60000
Molecular Function	GO:0003724	RNA helicase activity	ISO	J:164563
Molecular Function	GO:0003727	single-stranded RNA binding	ISO	J:164563
Molecular Function	GO:0003727	single-stranded RNA binding	IDA	J:182522
Molecular Function	GO:0003727	single-stranded RNA binding	IBA	J:265628
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Molecular Function	GO:0008270	zinc ion binding	ISO	J:164563
Molecular Function	GO:0008270	zinc ion binding	IBA	J:265628
Cellular Component	GO:0015629	actin cytoskeleton	ISO	J:164563
Cellular Component	GO:0005923	bicellular tight junction	ISO	J:164563
Cellular Component	GO:0030054	cell junction	IEA	J:60000
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-936387
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Cellular Component	GO:1990904	ribonucleoprotein complex	ISO	J:164563
Cellular Component	GO:0032587	ruffle membrane	ISO	J:164563
Biological Process	GO:0140374	antiviral innate immune response	ISO	J:164563
Biological Process	GO:0140374	antiviral innate immune response	IBA	J:265628
Biological Process	GO:0071360	cellular response to exogenous dsRNA	ISO	J:164563
Biological Process	GO:0002753	cytosolic pattern recognition receptor signaling pathway	ISO	J:164563
Biological Process	GO:0051607	defense response to virus	ISO	J:164563
Biological Process	GO:0009597	detection of virus	ISO	J:164563
Biological Process	GO:0010467	gene expression	IMP	J:290078
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0045087	innate immune response	IMP	J:183219
Biological Process	GO:0045087	innate immune response	ISO	J:164563
Biological Process	GO:0002230	positive regulation of defense response to virus by host	ISO	J:164563
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0032725	positive regulation of granulocyte macrophage colony-stimulating factor production	ISO	J:164563
Biological Process	GO:0032727	positive regulation of interferon-alpha production	ISO	J:164563
Biological Process	GO:0032728	positive regulation of interferon-beta production	IMP	J:183219
Biological Process	GO:0032728	positive regulation of interferon-beta production	ISO	J:164563
Biological Process	GO:0032728	positive regulation of interferon-beta production	ISO	J:280922
Biological Process	GO:0032755	positive regulation of interleukin-6 production	ISO	J:164563
Biological Process	GO:0032757	positive regulation of interleukin-8 production	ISO	J:164563
Biological Process	GO:0002735	positive regulation of myeloid dendritic cell cytokine production	IMP	J:173994
Biological Process	GO:0060760	positive regulation of response to cytokine stimulus	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	ISO	J:164563
Biological Process	GO:0030334	regulation of cell migration	ISO	J:164563
Biological Process	GO:0043330	response to exogenous dsRNA	IMP	J:173994
Biological Process	GO:0009615	response to virus	IMP	J:183219
Biological Process	GO:0039529	RIG-I signaling pathway	ISO	J:164563