GO Annotations Graph

• Symbol: Gen1
• Name: GEN1, Holliday junction 5' flap endonuclease
• ID: MGI:2443149

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0017108	5'-flap endonuclease activity	ISO	J:164563
Molecular Function	GO:0017108	5'-flap endonuclease activity	IBA	J:265628
Molecular Function	GO:0003824	catalytic activity	IEA	J:72247
Molecular Function	GO:0008821	crossover junction DNA endonuclease activity	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	IEA	J:72247
Molecular Function	GO:0004519	endonuclease activity	IEA	J:60000
Molecular Function	GO:0000400	four-way junction DNA binding	ISO	J:164563
Molecular Function	GO:0000400	four-way junction DNA binding	IBA	J:265628
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0000287	magnesium ion binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0004518	nuclease activity	IEA	J:72247
Molecular Function	GO:0004518	nuclease activity	IEA	J:60000
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Cellular Component	GO:0005813	centrosome	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IEA	J:60000
Biological Process	GO:0006974	DNA damage response	IEA	J:60000
Biological Process	GO:0006281	DNA repair	IEA	J:60000
Biological Process	GO:0000724	double-strand break repair via homologous recombination	ISO	J:164563
Biological Process	GO:0090267	positive regulation of mitotic cell cycle spindle assembly checkpoint	ISO	J:164563
Biological Process	GO:0010824	regulation of centrosome duplication	ISO	J:164563
Biological Process	GO:0031297	replication fork processing	ISO	J:164563
Biological Process	GO:0071140	resolution of mitotic recombination intermediates	ISO	J:164563
Biological Process	GO:0071139	resolution of recombination intermediates	ISO	J:164563