GO Annotations Graph

• Symbol: Map3k20
• Name: mitogen-activated protein kinase kinase kinase 20
• ID: MGI:2443258

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IDA	J:67266
Molecular Function	GO:0005524	ATP binding	ISO	J:164563
Molecular Function	GO:0004706	JUN kinase kinase kinase activity	ISO	J:164563
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0000287	magnesium ion binding	IDA	J:67266
Molecular Function	GO:0000287	magnesium ion binding	ISO	J:164563
Molecular Function	GO:0004709	MAP kinase kinase kinase activity	ISO	J:164563
Molecular Function	GO:0004709	MAP kinase kinase kinase activity	IBA	J:265628
Molecular Function	GO:0004709	MAP kinase kinase kinase activity	IDA	J:67266
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0030295	protein kinase activator activity	ISO	J:164563
Molecular Function	GO:0004672	protein kinase activity	IEA	J:72247
Molecular Function	GO:0043539	protein serine/threonine kinase activator activity	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:67266
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:164563
Molecular Function	GO:0043022	ribosome binding	ISO	J:164563
Molecular Function	GO:0003723	RNA binding	IEA	J:60000
Molecular Function	GO:0019843	rRNA binding	IEA	J:60000
Molecular Function	GO:0070181	small ribosomal subunit rRNA binding	ISO	J:164563
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0045182	translation regulator activity	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IDA	J:67266
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:67266
Biological Process	GO:0007049	cell cycle	IEA	J:60000
Biological Process	GO:0071480	cellular response to gamma radiation	ISO	J:164563
Biological Process	GO:0071493	cellular response to UV-B	ISO	J:164563
Biological Process	GO:0071493	cellular response to UV-B	ISO	J:164563
Biological Process	GO:0007010	cytoskeleton organization	IDA	J:67266
Biological Process	GO:0000077	DNA damage checkpoint signaling	ISO	J:164563
Biological Process	GO:0042733	embryonic digit morphogenesis	ISO	J:164563
Biological Process	GO:0140469	GCN2-mediated signaling	ISO	J:164563
Biological Process	GO:0035556	intracellular signal transduction	IDA	J:67266
Biological Process	GO:0007254	JNK cascade	IMP	J:241322
Biological Process	GO:0007254	JNK cascade	ISO	J:164563
Biological Process	GO:0060173	limb development	IMP	J:231477
Biological Process	GO:0060173	limb development	ISO	J:164563
Biological Process	GO:0000165	MAPK cascade	IDA	J:67266
Biological Process	GO:0070303	negative regulation of stress-activated protein kinase signaling cascade	ISO	J:164563
Biological Process	GO:1902010	negative regulation of translation in response to endoplasmic reticulum stress	ISO	J:164563
Biological Process	GO:0038066	p38MAPK cascade	IMP	J:241322
Biological Process	GO:0038066	p38MAPK cascade	ISO	J:164563
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:164563
Biological Process	GO:1904291	positive regulation of mitotic DNA damage checkpoint	ISO	J:164563
Biological Process	GO:0043068	positive regulation of programmed cell death	ISO	J:164563
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:164563
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	IDA	J:67266
Biological Process	GO:0006468	protein phosphorylation	ISO	J:164563
Biological Process	GO:0070269	pyroptosis	ISO	J:164563
Biological Process	GO:0051403	stress-activated MAPK cascade	IMP	J:328829
Biological Process	GO:0051403	stress-activated MAPK cascade	ISO	J:164563
Biological Process	GO:0031098	stress-activated protein kinase signaling cascade	ISO	J:164563
Biological Process	GO:0031098	stress-activated protein kinase signaling cascade	ISO	J:164563
Biological Process	GO:0031098	stress-activated protein kinase signaling cascade	IMP	J:241322