GO Annotations Graph

• Symbol: Tet2
• Name: tet methylcytosine dioxygenase 2
• ID: MGI:2443298

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0051213	dioxygenase activity	IEA	J:60000
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0008198	ferrous iron binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0070579	methylcytosine dioxygenase activity	IDA	J:175857
Molecular Function	GO:0070579	methylcytosine dioxygenase activity	IDA	J:148409
Molecular Function	GO:0070579	methylcytosine dioxygenase activity	ISO	J:164563
Molecular Function	GO:0070579	methylcytosine dioxygenase activity	IMP	J:168342
Molecular Function	GO:0070579	methylcytosine dioxygenase activity	IDA	J:175793
Molecular Function	GO:0070579	methylcytosine dioxygenase activity	IBA	J:265628
Molecular Function	GO:0070579	methylcytosine dioxygenase activity	IDA	J:163464
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:219967
Molecular Function	GO:0005515	protein binding	IPI	J:306583
Molecular Function	GO:0008270	zinc ion binding	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5220931
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5220936
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5220944
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IC	J:163464
Biological Process	GO:0006211	5-methylcytosine catabolic process	ISO	J:164563
Biological Process	GO:0019857	5-methylcytosine metabolic process	IMP	J:178415
Biological Process	GO:0007049	cell cycle	IEA	J:60000
Biological Process	GO:0006325	chromatin organization	IEA	J:60000
Biological Process	GO:0019858	cytosine metabolic process	IMP	J:178415
Biological Process	GO:0080111	DNA demethylation	TAS	J:175857
Biological Process	GO:0080111	DNA demethylation	ISO	J:164563
Biological Process	GO:0080111	DNA demethylation	TAS	J:175793
Biological Process	GO:0080111	DNA demethylation	IBA	J:265628
Biological Process	GO:0080111	DNA demethylation	IDA	J:163464
Biological Process	GO:0061484	hematopoietic stem cell homeostasis	IMP	J:178415
Biological Process	GO:0061484	hematopoietic stem cell homeostasis	IMP	J:178415
Biological Process	GO:0020027	hemoglobin metabolic process	IMP	J:178415
Biological Process	GO:0030097	hemopoiesis	IMP	J:174053
Biological Process	GO:0030097	hemopoiesis	IMP	J:174052
Biological Process	GO:0030097	hemopoiesis	IMP	J:175222
Biological Process	GO:0048872	homeostasis of number of cells	IMP	J:178415
Biological Process	GO:0001822	kidney development	IMP	J:140275
Biological Process	GO:0002521	leukocyte differentiation	ISO	J:164563
Biological Process	GO:0072576	liver morphogenesis	IMP	J:178415
Biological Process	GO:0030099	myeloid cell differentiation	ISO	J:164563
Biological Process	GO:0030099	myeloid cell differentiation	IMP	J:168342
Biological Process	GO:0030099	myeloid cell differentiation	IBA	J:265628
Biological Process	GO:0002318	myeloid progenitor cell differentiation	IMP	J:178415
Biological Process	GO:0070989	oxidative demethylation	IBA	J:265628
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:194478
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0009791	post-embryonic development	IMP	J:140275
Biological Process	GO:0006493	protein O-linked glycosylation	ISO	J:164563
Biological Process	GO:0006493	protein O-linked glycosylation	IMP	J:194478
Biological Process	GO:0048536	spleen development	IMP	J:178415