GO Annotations Graph

• Symbol: Trib1
• Name: tribbles pseudokinase 1
• ID: MGI:2443397

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0031434	mitogen-activated protein kinase kinase binding	ISO	J:164563
Molecular Function	GO:0031434	mitogen-activated protein kinase kinase binding	IBA	J:265628
Molecular Function	GO:0004860	protein kinase inhibitor activity	ISO	J:164563
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	IPI	J:126085
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0031625	ubiquitin protein ligase binding	IDA	J:161158
Molecular Function	GO:0055106	ubiquitin-protein transferase regulator activity	IDA	J:161158
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Biological Process	GO:0007254	JNK cascade	ISO	J:164563
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	IDA	J:126085
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	ISO	J:164563
Biological Process	GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0045659	negative regulation of neutrophil differentiation	IMP	J:196449
Biological Process	GO:0006469	negative regulation of protein kinase activity	ISO	J:164563
Biological Process	GO:0014912	negative regulation of smooth muscle cell migration	ISO	J:164563
Biological Process	GO:0048662	negative regulation of smooth muscle cell proliferation	ISO	J:164563
Biological Process	GO:0045645	positive regulation of eosinophil differentiation	IMP	J:196449
Biological Process	GO:0045651	positive regulation of macrophage differentiation	IMP	J:196449
Biological Process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IDA	J:161158
Biological Process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IBA	J:265628
Biological Process	GO:0051443	positive regulation of ubiquitin-protein transferase activity	IC	J:161158
Biological Process	GO:0043405	regulation of MAP kinase activity	ISO	J:164563
Biological Process	GO:0043405	regulation of MAP kinase activity	IBA	J:265628
Biological Process	GO:0032496	response to lipopolysaccharide	IMP	J:126085
Biological Process	GO:0032496	response to lipopolysaccharide	ISO	J:164563