GO Annotations Graph

• Symbol: Nr1d1
• Name: nuclear receptor subfamily 1, group D, member 1
• ID: MGI:2444210

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003677	DNA binding	IDA	J:23754
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:23754
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:78197
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0070888	E-box binding	IDA	J:141770
Molecular Function	GO:0020037	heme binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0004879	nuclear receptor activity	IBA	J:265628
Molecular Function	GO:0005515	protein binding	IPI	J:271698
Molecular Function	GO:0005515	protein binding	IPI	J:198046
Molecular Function	GO:0005515	protein binding	IPI	J:179782
Molecular Function	GO:0005515	protein binding	IPI	J:274080
Molecular Function	GO:0005515	protein binding	IPI	J:247279
Molecular Function	GO:0005515	protein binding	IPI	J:271692
Molecular Function	GO:0005515	protein binding	IPI	J:156994
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO	J:155827
Molecular Function	GO:0043565	sequence-specific DNA binding	IEA	J:72247
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:155856
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:164563
Molecular Function	GO:0000976	transcription cis-regulatory region binding	ISO	J:164563
Molecular Function	GO:0000976	transcription cis-regulatory region binding	ISO	J:155856
Molecular Function	GO:0001222	transcription corepressor binding	ISO	J:164563
Molecular Function	GO:0008270	zinc ion binding	IEA	J:72247
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0000785	chromatin	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IDA	J:179782
Cellular Component	GO:0005737	cytoplasm	IDA	J:273537
Cellular Component	GO:0005737	cytoplasm	IDA	J:247279
Cellular Component	GO:0030425	dendrite	IDA	J:179782
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0043197	dendritic spine	IDA	J:179782
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0016604	nuclear body	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-549505
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5667077
Cellular Component	GO:0005634	nucleus	IDA	J:273537
Cellular Component	GO:0005634	nucleus	IDA	J:247279
Cellular Component	GO:0005634	nucleus	IDA	J:179782
Cellular Component	GO:0005634	nucleus	IDA	J:78197
Cellular Component	GO:0045202	synapse	IEA	J:60000
Biological Process	GO:0030154	cell differentiation	IBA	J:265628
Biological Process	GO:0071347	cellular response to interleukin-1	IDA	J:264705
Biological Process	GO:0071222	cellular response to lipopolysaccharide	ISO	J:164563
Biological Process	GO:0071356	cellular response to tumor necrosis factor	IDA	J:264705
Biological Process	GO:0042632	cholesterol homeostasis	IMP	J:153064
Biological Process	GO:0032922	circadian regulation of gene expression	IMP	J:156994
Biological Process	GO:0007623	circadian rhythm	IEP	J:207820
Biological Process	GO:0007623	circadian rhythm	IDA	J:78197
Biological Process	GO:0060086	circadian temperature homeostasis	IMP	J:203422
Biological Process	GO:0005978	glycogen biosynthetic process	IMP	J:156994
Biological Process	GO:0009755	hormone-mediated signaling pathway	IBA	J:265628
Biological Process	GO:0001678	intracellular glucose homeostasis	ISO	J:164563
Biological Process	GO:0061889	negative regulation of astrocyte activation	IMP	J:273176
Biological Process	GO:0120163	negative regulation of cold-induced thermogenesis	IMP	J:203422
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IMP	J:203422
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IDA	J:271698
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IDA	J:266297
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IMP	J:153064
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IMP	J:141770
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IDA	J:271712
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IMP	J:273176
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IDA	J:179782
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IMP	J:273552
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IDA	J:211323
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IMP	J:134207
Biological Process	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	IMP	J:273176
Biological Process	GO:0050728	negative regulation of inflammatory response	IMP	J:264705
Biological Process	GO:1903979	negative regulation of microglial cell activation	IMP	J:273176
Biological Process	GO:0150079	negative regulation of neuroinflammatory response	IMP	J:273176
Biological Process	GO:0034144	negative regulation of toll-like receptor 4 signaling pathway	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:155827
Biological Process	GO:0070859	positive regulation of bile acid biosynthetic process	IMP	J:141770
Biological Process	GO:0070859	positive regulation of bile acid biosynthetic process	IMP	J:153064
Biological Process	GO:0042753	positive regulation of circadian rhythm	ISO	J:155856
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:155856
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IMP	J:141770
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0010498	proteasomal protein catabolic process	IDA	J:179782
Biological Process	GO:0010498	proteasomal protein catabolic process	IDA	J:134207
Biological Process	GO:0031648	protein destabilization	IMP	J:247279
Biological Process	GO:0042752	regulation of circadian rhythm	IMP	J:153064
Biological Process	GO:0042752	regulation of circadian rhythm	IMP	J:156994
Biological Process	GO:0042752	regulation of circadian rhythm	ISO	J:155856
Biological Process	GO:0042752	regulation of circadian rhythm	IMP	J:264705
Biological Process	GO:0042749	regulation of circadian sleep/wake cycle	IMP	J:273176
Biological Process	GO:0006355	regulation of DNA-templated transcription	IDA	J:23754
Biological Process	GO:0045598	regulation of fat cell differentiation	IMP	J:134207
Biological Process	GO:2000489	regulation of hepatic stellate cell activation	ISO	J:155856
Biological Process	GO:0061178	regulation of insulin secretion involved in cellular response to glucose stimulus	IMP	J:181732
Biological Process	GO:0019216	regulation of lipid metabolic process	IMP	J:153064
Biological Process	GO:0019216	regulation of lipid metabolic process	IMP	J:181732
Biological Process	GO:0061469	regulation of type B pancreatic cell proliferation	IMP	J:181732
Biological Process	GO:0044321	response to leptin	IDA	J:181732
Biological Process	GO:0044321	response to leptin	IBA	J:265628
Biological Process	GO:0048511	rhythmic process	IEA	J:60000