GO Annotations Graph

• Symbol: Madd
• Name: MAP-kinase activating death domain
• ID: MGI:2444672

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	ISO	J:164563
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	ISO	J:155856
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	IBA	J:265628
Cellular Component	GO:0030424	axon	IDA	J:263424
Cellular Component	GO:1904115	axon cytoplasm	IDA	J:263424
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0045202	synapse	ISO	J:155856
Cellular Component	GO:0045202	synapse	ISO	J:155856
Cellular Component	GO:0008021	synaptic vesicle	ISO	J:155856
Biological Process	GO:0048490	anterograde synaptic vesicle transport	IDA	J:263424
Biological Process	GO:0048490	anterograde synaptic vesicle transport	IDA	J:263424
Biological Process	GO:0048490	anterograde synaptic vesicle transport	IMP	J:263424
Biological Process	GO:0048490	anterograde synaptic vesicle transport	IMP	J:263424
Biological Process	GO:0048490	anterograde synaptic vesicle transport	IDA	J:263424
Biological Process	GO:0006915	apoptotic process	IEA	J:60000
Biological Process	GO:0097194	execution phase of apoptosis	ISO	J:164563
Biological Process	GO:0097194	execution phase of apoptosis	IMP	J:118809
Biological Process	GO:2001234	negative regulation of apoptotic signaling pathway	IMP	J:118809
Biological Process	GO:0060125	negative regulation of growth hormone secretion	ISO	J:155856
Biological Process	GO:1902277	negative regulation of pancreatic amylase secretion	ISO	J:155856
Biological Process	GO:0043410	positive regulation of MAPK cascade	ISO	J:164563
Biological Process	GO:0042981	regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0042981	regulation of apoptotic process	IBA	J:265628
Biological Process	GO:0051726	regulation of cell cycle	IMP	J:118809
Biological Process	GO:0051726	regulation of cell cycle	ISO	J:164563
Biological Process	GO:2001236	regulation of extrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:1902041	regulation of extrinsic apoptotic signaling pathway via death domain receptors	ISO	J:164563
Biological Process	GO:0032483	regulation of Rab protein signal transduction	ISO	J:164563
Biological Process	GO:0032483	regulation of Rab protein signal transduction	IBA	J:265628