GO Annotations Graph

• Symbol: Mavs
• Name: mitochondrial antiviral signaling protein
• ID: MGI:2444773

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0050700	CARD domain binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0060090	molecular adaptor activity	ISO	J:164563
Molecular Function	GO:0140693	molecular condensate scaffold activity	ISO	J:164563
Molecular Function	GO:0140677	molecular function activator activity	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:200433
Molecular Function	GO:0005515	protein binding	IPI	J:257328
Molecular Function	GO:0005515	protein binding	IPI	J:144594
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0039552	RIG-I binding	ISO	J:164563
Molecular Function	GO:0035591	signaling adaptor activity	ISO	J:164563
Molecular Function	GO:0035591	signaling adaptor activity	IMP	J:167950
Molecular Function	GO:0035591	signaling adaptor activity	IDA	J:197368
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0031966	mitochondrial membrane	ISO	J:164563
Cellular Component	GO:0031966	mitochondrial membrane	ISO	J:164563
Cellular Component	GO:0005741	mitochondrial outer membrane	ISO	J:164563
Cellular Component	GO:0005741	mitochondrial outer membrane	TAS	Reactome:R-MMU-936387
Cellular Component	GO:0005739	mitochondrion	IDA	J:167950
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	IDA	J:197368
Cellular Component	GO:0005739	mitochondrion	HDA	J:151002
Cellular Component	GO:0005739	mitochondrion	IDA	J:280922
Cellular Component	GO:0005778	peroxisomal membrane	ISO	J:164563
Cellular Component	GO:0005777	peroxisome	IDA	J:167950
Cellular Component	GO:0005777	peroxisome	IDA	J:186390
Biological Process	GO:0002218	activation of innate immune response	ISO	J:164563
Biological Process	GO:0140374	antiviral innate immune response	ISO	J:164563
Biological Process	GO:0071360	cellular response to exogenous dsRNA	ISO	J:164563
Biological Process	GO:0035458	cellular response to interferon-beta	ISO	J:280922
Biological Process	GO:0002753	cytosolic pattern recognition receptor signaling pathway	ISO	J:164563
Biological Process	GO:0042742	defense response to bacterium	ISO	J:164563
Biological Process	GO:0051607	defense response to virus	ISO	J:164563
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0045087	innate immune response	ISO	J:164563
Biological Process	GO:0045071	negative regulation of viral genome replication	IMP	J:167950
Biological Process	GO:0045071	negative regulation of viral genome replication	ISO	J:164563
Biological Process	GO:0071651	positive regulation of chemokine (C-C motif) ligand 5 production	ISO	J:164563
Biological Process	GO:0002230	positive regulation of defense response to virus by host	ISO	J:164563
Biological Process	GO:0002230	positive regulation of defense response to virus by host	IMP	J:139074
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	ISO	J:164563
Biological Process	GO:0032727	positive regulation of interferon-alpha production	ISO	J:164563
Biological Process	GO:0032727	positive regulation of interferon-alpha production	IMP	J:280922
Biological Process	GO:0032728	positive regulation of interferon-beta production	ISO	J:164563
Biological Process	GO:0032728	positive regulation of interferon-beta production	IMP	J:280922
Biological Process	GO:0032755	positive regulation of interleukin-6 production	ISO	J:164563
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IMP	J:280922
Biological Process	GO:0032757	positive regulation of interleukin-8 production	ISO	J:164563
Biological Process	GO:0071660	positive regulation of IP-10 production	ISO	J:164563
Biological Process	GO:0002735	positive regulation of myeloid dendritic cell cytokine production	IMP	J:173994
Biological Process	GO:1900227	positive regulation of NLRP3 inflammasome complex assembly	ISO	J:164563
Biological Process	GO:1900227	positive regulation of NLRP3 inflammasome complex assembly	IDA	J:197368
Biological Process	GO:0090073	positive regulation of protein homodimerization activity	ISO	J:280922
Biological Process	GO:0042307	positive regulation of protein import into nucleus	ISO	J:164563
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:164563
Biological Process	GO:0060760	positive regulation of response to cytokine stimulus	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	ISO	J:164563
Biological Process	GO:0032481	positive regulation of type I interferon production	ISO	J:164563
Biological Process	GO:0032481	positive regulation of type I interferon production	IMP	J:139074
Biological Process	GO:0060340	positive regulation of type I interferon-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0070585	protein localization to mitochondrion	IDA	J:197368
Biological Process	GO:0070585	protein localization to mitochondrion	ISO	J:164563
Biological Process	GO:0051262	protein tetramerization	ISO	J:280922
Biological Process	GO:1900063	regulation of peroxisome organization	ISO	J:164563
Biological Process	GO:1900063	regulation of peroxisome organization	IMP	J:167950
Biological Process	GO:0039529	RIG-I signaling pathway	IGI	J:186390
Biological Process	GO:0007165	signal transduction	ISO	J:164563
Biological Process	GO:0007165	signal transduction	IMP	J:167950