GO Annotations Graph

• Symbol: Chfr
• Name: checkpoint with forkhead and ring finger domains
• ID: MGI:2444898

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:181256
Molecular Function	GO:0005515	protein binding	IPI	J:181256
Molecular Function	GO:0005515	protein binding	IPI	J:181256
Molecular Function	GO:0005515	protein binding	IPI	J:97428
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0061630	ubiquitin protein ligase activity	IMP	J:97428
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	ISO	J:164563
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	IBA	J:265628
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0016605	PML body	ISO	J:164563
Biological Process	GO:0007049	cell cycle	IEA	J:60000
Biological Process	GO:0051301	cell division	IEA	J:60000
Biological Process	GO:0044779	meiotic spindle checkpoint signaling	ISO	J:164563
Biological Process	GO:0000278	mitotic cell cycle	IMP	J:97428
Biological Process	GO:0007093	mitotic cell cycle checkpoint signaling	IBA	J:265628
Biological Process	GO:0044818	mitotic G2/M transition checkpoint	ISO	J:164563
Biological Process	GO:0019941	modification-dependent protein catabolic process	ISO	J:164563
Biological Process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IDA	J:181256
Biological Process	GO:0031398	positive regulation of protein ubiquitination	IDA	J:181256
Biological Process	GO:0031648	protein destabilization	IDA	J:181256
Biological Process	GO:0000209	protein polyubiquitination	ISO	J:164563
Biological Process	GO:0000209	protein polyubiquitination	IDA	J:97428
Biological Process	GO:0016567	protein ubiquitination	IBA	J:265628
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	IBA	J:265628
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	IDA	J:97428