GO Annotations Graph

• Symbol: Malt1
• Name: MALT1 paracaspase
• ID: MGI:2445027

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	IEA	J:72247
Molecular Function	GO:0004175	endopeptidase activity	ISO	J:164563
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0019209	kinase activator activity	ISO	J:164563
Molecular Function	GO:0008233	peptidase activity	ISO	J:164563
Molecular Function	GO:0002020	protease binding	IPI	J:169886
Molecular Function	GO:0005515	protein binding	IPI	J:112532
Molecular Function	GO:0043621	protein self-association	ISO	J:164563
Molecular Function	GO:0036094	small molecule binding	ISO	J:164563
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	ISO	J:164563
Cellular Component	GO:0032449	CBM complex	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005829	cytosol	IDA	J:116495
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-2730893
Cellular Component	GO:0001650	fibrillar center	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0002096	polkadots	IDA	J:112532
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Biological Process	GO:0007250	activation of NF-kappaB-inducing kinase activity	ISO	J:164563
Biological Process	GO:0006915	apoptotic process	RCA	J:84168
Biological Process	GO:0042113	B cell activation	IBA	J:265628
Biological Process	GO:0042113	B cell activation	IMP	J:86770
Biological Process	GO:0001923	B-1 B cell differentiation	IMP	J:109545
Biological Process	GO:0071222	cellular response to lipopolysaccharide	IEP	J:116495
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	RCA	J:84168
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0045087	innate immune response	IEP	J:116495
Biological Process	GO:0045087	innate immune response	IBA	J:265628
Biological Process	GO:0031663	lipopolysaccharide-mediated signaling pathway	IDA	J:116495
Biological Process	GO:0051168	nuclear export	ISO	J:164563
Biological Process	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISO	J:164563
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	ISO	J:164563
Biological Process	GO:0032743	positive regulation of interleukin-2 production	ISO	J:164563
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	ISO	J:164563
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	IBA	J:265628
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	IMP	J:109545
Biological Process	GO:0050870	positive regulation of T cell activation	IMP	J:109545
Biological Process	GO:0002726	positive regulation of T cell cytokine production	ISO	J:164563
Biological Process	GO:2000321	positive regulation of T-helper 17 cell differentiation	IDA	J:259145
Biological Process	GO:0006508	proteolysis	IDA	J:259145
Biological Process	GO:0006508	proteolysis	ISO	J:164563
Biological Process	GO:0051603	proteolysis involved in protein catabolic process	ISO	J:164563
Biological Process	GO:0042981	regulation of apoptotic process	ISO	J:84168
Biological Process	GO:0050856	regulation of T cell receptor signaling pathway	IMP	J:109545
Biological Process	GO:0009620	response to fungus	IMP	J:111706
Biological Process	GO:0042098	T cell proliferation	IMP	J:86770
Biological Process	GO:0050852	T cell receptor signaling pathway	IDA	J:259145
Biological Process	GO:0050852	T cell receptor signaling pathway	ISO	J:164563
Biological Process	GO:0050852	T cell receptor signaling pathway	IBA	J:265628