GO Annotations Graph

• Symbol: Sik2
• Name: salt inducible kinase 2
• ID: MGI:2445031

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	ISO	J:164563
Molecular Function	GO:0005524	ATP binding	IDA	J:83587
Molecular Function	GO:0008047	enzyme activator activity	ISO	J:164563
Molecular Function	GO:0004857	enzyme inhibitor activity	ISO	J:164563
Molecular Function	GO:0004857	enzyme inhibitor activity	IMP	J:171868
Molecular Function	GO:0004857	enzyme inhibitor activity	IDA	J:171868
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0000287	magnesium ion binding	ISO	J:164563
Molecular Function	GO:0000287	magnesium ion binding	IDA	J:83587
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0060589	nucleoside-triphosphatase regulator activity	ISO	J:164563
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:212985
Molecular Function	GO:0004672	protein kinase activity	IEA	J:72247
Molecular Function	GO:0106310	protein serine kinase activity	ISO	J:164563
Molecular Function	GO:0106310	protein serine kinase activity	IMP	J:171868
Molecular Function	GO:0106310	protein serine kinase activity	IDA	J:171868
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IBA	J:265628
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:83587
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	IDA	J:83587
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005789	endoplasmic reticulum membrane	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:83587
Biological Process	GO:0008286	insulin receptor signaling pathway	IDA	J:83587
Biological Process	GO:0035556	intracellular signal transduction	IDA	J:83587
Biological Process	GO:0035556	intracellular signal transduction	ISO	J:164563
Biological Process	GO:0035556	intracellular signal transduction	IBA	J:265628
Biological Process	GO:0045820	negative regulation of glycolytic process	IMP	J:171868
Biological Process	GO:0051055	negative regulation of lipid biosynthetic process	IDA	J:171868
Biological Process	GO:0061987	negative regulation of transcription from RNA polymerase II promoter by glucose	IMP	J:171868
Biological Process	GO:0061987	negative regulation of transcription from RNA polymerase II promoter by glucose	IDA	J:171868
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	IBA	J:265628
Biological Process	GO:0006468	protein phosphorylation	IDA	J:83587
Biological Process	GO:0046626	regulation of insulin receptor signaling pathway	IDA	J:83587