GO Annotations Graph

• Symbol: Klhl3
• Name: kelch-like 3
• ID: MGI:2445185

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003779	actin binding	IEA	J:60000
Molecular Function	GO:0097602	cullin family protein binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:216684
Molecular Function	GO:0005515	protein binding	IPI	J:197369
Molecular Function	GO:0005515	protein binding	IPI	J:214330
Molecular Function	GO:0005515	protein binding	IPI	J:217619
Molecular Function	GO:0005515	protein binding	IPI	J:197369
Molecular Function	GO:0005515	protein binding	IPI	J:214330
Cellular Component	GO:0031463	Cul3-RING ubiquitin ligase complex	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Biological Process	GO:0072156	distal tubule morphogenesis	ISO	J:164563
Biological Process	GO:0010467	gene expression	IMP	J:197369
Biological Process	GO:0010467	gene expression	IGI	J:251049
Biological Process	GO:0010467	gene expression	IMP	J:214330
Biological Process	GO:0010467	gene expression	IDA	J:197369
Biological Process	GO:0008152	metabolic process	IMP	J:214330
Biological Process	GO:0050801	monoatomic ion homeostasis	ISO	J:164563
Biological Process	GO:0050801	monoatomic ion homeostasis	IBA	J:265628
Biological Process	GO:0050801	monoatomic ion homeostasis	IMP	J:197369
Biological Process	GO:0055075	potassium ion homeostasis	IMP	J:214330
Biological Process	GO:0030163	protein catabolic process	IMP	J:197369
Biological Process	GO:0030163	protein catabolic process	IMP	J:216684
Biological Process	GO:0070936	protein K48-linked ubiquitination	ISO	J:164563
Biological Process	GO:0070936	protein K48-linked ubiquitination	IBA	J:265628
Biological Process	GO:0006468	protein phosphorylation	IMP	J:214330
Biological Process	GO:0006468	protein phosphorylation	IGI	J:251049
Biological Process	GO:0000209	protein polyubiquitination	IDA	J:197369
Biological Process	GO:0000209	protein polyubiquitination	IMP	J:197369
Biological Process	GO:0016567	protein ubiquitination	ISO	J:164563
Biological Process	GO:0070293	renal absorption	IMP	J:214330
Biological Process	GO:0070294	renal sodium ion absorption	ISO	J:164563
Biological Process	GO:0070294	renal sodium ion absorption	IBA	J:265628
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	ISO	J:164563