GO Annotations Graph

• Symbol: Pde2a
• Name: phosphodiesterase 2A, cGMP-stimulated
• ID: MGI:2446107

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	IMP	J:177215
Molecular Function	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	ISO	J:164563
Molecular Function	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	ISO	J:164563
Molecular Function	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	IBA	J:265628
Molecular Function	GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity	IMP	J:177215
Molecular Function	GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity	ISO	J:164563
Molecular Function	GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity	ISO	J:164563
Molecular Function	GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity	IBA	J:265628
Molecular Function	GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	IEA	J:72245
Molecular Function	GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	IEA	J:72247
Molecular Function	GO:0030552	cAMP binding	IMP	J:177163
Molecular Function	GO:0030552	cAMP binding	ISO	J:164563
Molecular Function	GO:0030553	cGMP binding	ISO	J:164563
Molecular Function	GO:0030553	cGMP binding	IDA	J:177169
Molecular Function	GO:0030553	cGMP binding	IMP	J:177163
Molecular Function	GO:0004118	cGMP-stimulated cyclic-nucleotide phosphodiesterase activity	IDA	J:177163
Molecular Function	GO:0004118	cGMP-stimulated cyclic-nucleotide phosphodiesterase activity	ISO	J:164563
Molecular Function	GO:0004118	cGMP-stimulated cyclic-nucleotide phosphodiesterase activity	IBA	J:265628
Molecular Function	GO:0036004	GAF domain binding	IDA	J:177169
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0000287	magnesium ion binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0042301	phosphate ion binding	ISO	J:164563
Molecular Function	GO:0008081	phosphoric diester hydrolase activity	IEA	J:72247
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0042803	protein homodimerization activity	IDA	J:177169
Molecular Function	GO:0042803	protein homodimerization activity	IBA	J:265628
Molecular Function	GO:0030911	TPR domain binding	ISO	J:164563
Molecular Function	GO:0008270	zinc ion binding	ISO	J:164563
Cellular Component	GO:0030424	axon	IDA	J:28665
Cellular Component	GO:0005737	cytoplasm	IDA	J:177228
Cellular Component	GO:0005737	cytoplasm	IDA	J:154140
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	IDA	J:156361
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0005829	cytosol	IDA	J:177157
Cellular Component	GO:0030425	dendrite	IDA	J:28665
Cellular Component	GO:0005783	endoplasmic reticulum	IDA	J:156361
Cellular Component	GO:0005794	Golgi apparatus	IDA	J:156361
Cellular Component	GO:0097457	hippocampal mossy fiber	ISO	J:155856
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0045121	membrane raft	ISO	J:155856
Cellular Component	GO:0005743	mitochondrial inner membrane	ISO	J:164563
Cellular Component	GO:0005743	mitochondrial inner membrane	IDA	J:243434
Cellular Component	GO:0005743	mitochondrial inner membrane	ISO	J:155856
Cellular Component	GO:0005743	mitochondrial inner membrane	IBA	J:265628
Cellular Component	GO:0005759	mitochondrial matrix	IDA	J:177215
Cellular Component	GO:0005759	mitochondrial matrix	ISO	J:155856
Cellular Component	GO:0005759	mitochondrial matrix	IBA	J:265628
Cellular Component	GO:0005741	mitochondrial outer membrane	IDA	J:243434
Cellular Component	GO:0005741	mitochondrial outer membrane	ISO	J:164563
Cellular Component	GO:0005741	mitochondrial outer membrane	ISO	J:155856
Cellular Component	GO:0005741	mitochondrial outer membrane	IBA	J:265628
Cellular Component	GO:0005739	mitochondrion	IDA	J:243434
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:156361
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0048471	perinuclear region of cytoplasm	IDA	J:156361
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Cellular Component	GO:0048471	perinuclear region of cytoplasm	IBA	J:265628
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IDA	J:156361
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0042734	presynaptic membrane	IDA	J:154140
Cellular Component	GO:0097060	synaptic membrane	ISO	J:155856
Cellular Component	GO:0097060	synaptic membrane	IBA	J:265628
Biological Process	GO:0007193	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	ISO	J:164563
Biological Process	GO:0035904	aorta development	IMP	J:222159
Biological Process	GO:0019933	cAMP-mediated signaling	IDA	J:177163
Biological Process	GO:0019933	cAMP-mediated signaling	NAS	J:154140
Biological Process	GO:0019933	cAMP-mediated signaling	ISO	J:164563
Biological Process	GO:0019933	cAMP-mediated signaling	IBA	J:265628
Biological Process	GO:0003279	cardiac septum development	IMP	J:222159
Biological Process	GO:1904613	cellular response to 2,3,7,8-tetrachlorodibenzodioxine	ISO	J:164563
Biological Process	GO:0071320	cellular response to cAMP	ISO	J:164563
Biological Process	GO:0071321	cellular response to cGMP	ISO	J:164563
Biological Process	GO:0097011	cellular response to granulocyte macrophage colony-stimulating factor stimulus	ISO	J:164563
Biological Process	GO:0071222	cellular response to lipopolysaccharide	IEP	J:177228
Biological Process	GO:0036006	cellular response to macrophage colony-stimulating factor stimulus	ISO	J:164563
Biological Process	GO:0071260	cellular response to mechanical stimulus	IDA	J:177228
Biological Process	GO:0046069	cGMP catabolic process	IMP	J:156361
Biological Process	GO:0046069	cGMP catabolic process	ISO	J:164563
Biological Process	GO:0046069	cGMP catabolic process	IBA	J:265628
Biological Process	GO:0019934	cGMP-mediated signaling	NAS	J:154140
Biological Process	GO:0019934	cGMP-mediated signaling	IDA	J:177163
Biological Process	GO:0019934	cGMP-mediated signaling	ISO	J:164563
Biological Process	GO:0019934	cGMP-mediated signaling	IBA	J:265628
Biological Process	GO:0060976	coronary vasculature development	IMP	J:222159
Biological Process	GO:0061028	establishment of endothelial barrier	ISO	J:155856
Biological Process	GO:0007507	heart development	IMP	J:222159
Biological Process	GO:0003170	heart valve development	IMP	J:222159
Biological Process	GO:0043951	negative regulation of cAMP-mediated signaling	IMP	J:177215
Biological Process	GO:0043951	negative regulation of cAMP-mediated signaling	ISO	J:155856
Biological Process	GO:0043951	negative regulation of cAMP-mediated signaling	IMP	J:177228
Biological Process	GO:0043951	negative regulation of cAMP-mediated signaling	ISO	J:164563
Biological Process	GO:0043951	negative regulation of cAMP-mediated signaling	IBA	J:265628
Biological Process	GO:0060548	negative regulation of cell death	IMP	J:243434
Biological Process	GO:0060548	negative regulation of cell death	ISO	J:155856
Biological Process	GO:0010754	negative regulation of cGMP-mediated signaling	IMP	J:177215
Biological Process	GO:0010754	negative regulation of cGMP-mediated signaling	IBA	J:265628
Biological Process	GO:0090324	negative regulation of oxidative phosphorylation	IMP	J:177215
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0043116	negative regulation of vascular permeability	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:177228
Biological Process	GO:0010628	positive regulation of gene expression	IBA	J:265628
Biological Process	GO:0050729	positive regulation of inflammatory response	IMP	J:177228
Biological Process	GO:0043117	positive regulation of vascular permeability	ISO	J:164563
Biological Process	GO:0043949	regulation of cAMP-mediated signaling	ISO	J:164563
Biological Process	GO:0010752	regulation of cGMP-mediated signaling	ISO	J:164563
Biological Process	GO:0010821	regulation of mitochondrion organization	IMP	J:243434
Biological Process	GO:0010821	regulation of mitochondrion organization	ISO	J:155856
Biological Process	GO:0010821	regulation of mitochondrion organization	IBA	J:265628
Biological Process	GO:0010749	regulation of nitric oxide mediated signal transduction	IGI	J:101420
Biological Process	GO:0007165	signal transduction	IEA	J:72247
Biological Process	GO:0003281	ventricular septum development	IMP	J:222159