GO Annotations Graph

• Symbol: Ago2
• Name: argonaute RISC catalytic subunit 2
• ID: MGI:2446632

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0001046	core promoter sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0003725	double-stranded RNA binding	ISO	J:164563
Molecular Function	GO:0004519	endonuclease activity	IEA	J:60000
Molecular Function	GO:0090624	endoribonuclease activity, cleaving miRNA-paired mRNA	ISO	J:164563
Molecular Function	GO:0070551	endoribonuclease activity, cleaving siRNA-paired mRNA	ISO	J:164563
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0035198	miRNA binding	ISO	J:164563
Molecular Function	GO:0035198	miRNA binding	IBA	J:265628
Molecular Function	GO:0035198	miRNA binding	IMP	J:188024
Molecular Function	GO:0035198	miRNA binding	IDA	J:201967
Molecular Function	GO:0035198	miRNA binding	IDA	J:200238
Molecular Function	GO:0035925	mRNA 3'-UTR AU-rich region binding	ISO	J:164563
Molecular Function	GO:0003729	mRNA binding	IDA	J:167546
Molecular Function	GO:0003729	mRNA binding	IDA	J:201967
Molecular Function	GO:0098808	mRNA cap binding	ISO	J:164563
Molecular Function	GO:0004518	nuclease activity	IEA	J:60000
Molecular Function	GO:0003676	nucleic acid binding	IEA	J:72247
Molecular Function	GO:0005515	protein binding	IPI	J:245279
Molecular Function	GO:0005515	protein binding	IPI	J:221791
Molecular Function	GO:0005515	protein binding	IPI	J:260599
Molecular Function	GO:0005515	protein binding	IPI	J:245315
Molecular Function	GO:0005515	protein binding	IPI	J:190251
Molecular Function	GO:0005515	protein binding	IPI	J:158290
Molecular Function	GO:0005515	protein binding	IPI	J:245305
Molecular Function	GO:0005515	protein binding	IPI	J:92289
Molecular Function	GO:0005515	protein binding	IPI	J:277871
Molecular Function	GO:0000340	RNA 7-methylguanosine cap binding	ISO	J:164563
Molecular Function	GO:0003723	RNA binding	IDA	J:150716
Molecular Function	GO:0004521	RNA endonuclease activity	ISO	J:164563
Molecular Function	GO:0004521	RNA endonuclease activity	IBA	J:265628
Molecular Function	GO:0004521	RNA endonuclease activity	IDA	J:161968
Molecular Function	GO:0000993	RNA polymerase II complex binding	ISO	J:164563
Molecular Function	GO:0003727	single-stranded RNA binding	ISO	J:164563
Molecular Function	GO:0035197	siRNA binding	ISO	J:164563
Molecular Function	GO:0035197	siRNA binding	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:156954
Cellular Component	GO:0036464	cytoplasmic ribonucleoprotein granule	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	IDA	J:197739
Cellular Component	GO:0030425	dendrite	IDA	J:179583
Cellular Component	GO:0070062	extracellular exosome	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005845	mRNA cap binding complex	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:197739
Cellular Component	GO:0000932	P-body	IDA	J:158290
Cellular Component	GO:0000932	P-body	ISO	J:73065
Cellular Component	GO:0005844	polysome	ISO	J:164563
Cellular Component	GO:1990904	ribonucleoprotein complex	ISO	J:164563
Cellular Component	GO:1990904	ribonucleoprotein complex	IDA	J:211935
Cellular Component	GO:0016442	RISC complex	IDA	J:217997
Cellular Component	GO:0016442	RISC complex	IDA	J:188024
Cellular Component	GO:0016442	RISC complex	IDA	J:150716
Cellular Component	GO:0016442	RISC complex	IDA	J:161968
Cellular Component	GO:0016442	RISC complex	ISO	J:73065
Cellular Component	GO:0070578	RISC-loading complex	IDA	J:217997
Cellular Component	GO:0070578	RISC-loading complex	ISO	J:164563
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0010586	miRNA metabolic process	IDA	J:197739
Biological Process	GO:0035196	miRNA processing	ISO	J:164563
Biological Process	GO:0035196	miRNA processing	IMP	J:161968
Biological Process	GO:0035278	miRNA-mediated gene silencing by inhibition of translation	ISO	J:164563
Biological Process	GO:0035279	miRNA-mediated gene silencing by mRNA destabilization	IDA	J:217997
Biological Process	GO:0035279	miRNA-mediated gene silencing by mRNA destabilization	ISO	J:164563
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0042985	negative regulation of amyloid precursor protein biosynthetic process	ISO	J:155856
Biological Process	GO:0045947	negative regulation of translational initiation	ISO	J:164563
Biological Process	GO:0045766	positive regulation of angiogenesis	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:197739
Biological Process	GO:1900153	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	IMP	J:196089
Biological Process	GO:0060213	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	IMP	J:196089
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045727	positive regulation of translation	ISO	J:164563
Biological Process	GO:1901165	positive regulation of trophoblast cell migration	ISO	J:164563
Biological Process	GO:0009791	post-embryonic development	IMP	J:161968
Biological Process	GO:0031054	pre-miRNA processing	IDA	J:217997
Biological Process	GO:0031054	pre-miRNA processing	ISO	J:164563
Biological Process	GO:0006355	regulation of DNA-templated transcription	IEA	J:72247
Biological Process	GO:0006417	regulation of translation	IEA	J:60000
Biological Process	GO:0070922	RISC complex assembly	ISO	J:164563
Biological Process	GO:0010501	RNA secondary structure unwinding	ISO	J:164563
Biological Process	GO:0031047	RNA-mediated gene silencing	IMP	J:196089
Biological Process	GO:0030422	siRNA processing	ISO	J:164563
Biological Process	GO:0090625	siRNA-mediated gene silencing by mRNA destabilization	ISO	J:164563