GO Annotations Graph

• Symbol: Slc24a4
• Name: solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
• ID: MGI:2447362

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0015297	antiporter activity	IEA	J:60000
Molecular Function	GO:0005262	calcium channel activity	IBA	J:265628
Molecular Function	GO:0008273	calcium, potassium:sodium antiporter activity	IDA	J:306705
Molecular Function	GO:0008273	calcium, potassium:sodium antiporter activity	ISO	J:164563
Molecular Function	GO:0008273	calcium, potassium:sodium antiporter activity	IBA	J:265628
Molecular Function	GO:0008273	calcium, potassium:sodium antiporter activity	ISA	J:80562
Molecular Function	GO:0048306	calcium-dependent protein binding	IPI	J:306604
Molecular Function	GO:0005432	calcium:sodium antiporter activity	ISA	J:80562
Molecular Function	GO:0005516	calmodulin binding	IPI	J:306604
Molecular Function	GO:0015293	symporter activity	IEA	J:60000
Cellular Component	GO:0016324	apical plasma membrane	IDA	J:306590
Cellular Component	GO:0016324	apical plasma membrane	IDA	J:306592
Cellular Component	GO:0120199	cone photoreceptor outer segment	IDA	J:256858
Cellular Component	GO:0005737	cytoplasm	IDA	J:213878
Cellular Component	GO:0016020	membrane	IDA	J:306604
Cellular Component	GO:0016020	membrane	IDA	J:213878
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IDA	J:306594
Cellular Component	GO:0005886	plasma membrane	IC	J:80562
Cellular Component	GO:0005886	plasma membrane	IDA	J:242792
Cellular Component	GO:0031982	vesicle	IDA	J:306604
Biological Process	GO:0097186	amelogenesis	IMP	J:202571
Biological Process	GO:0097186	amelogenesis	IMP	J:306592
Biological Process	GO:1990034	calcium ion export across plasma membrane	IDA	J:306604
Biological Process	GO:0055074	calcium ion homeostasis	IMP	J:306585
Biological Process	GO:0098703	calcium ion import across plasma membrane	IDA	J:306705
Biological Process	GO:0070588	calcium ion transmembrane transport	ISA	J:80562
Biological Process	GO:0070588	calcium ion transmembrane transport	ISO	J:164563
Biological Process	GO:0070588	calcium ion transmembrane transport	IBA	J:265628
Biological Process	GO:0006816	calcium ion transport	IEA	J:60000
Biological Process	GO:0071486	cellular response to high light intensity	IMP	J:256858
Biological Process	GO:0036368	cone photoresponse recovery	IMP	J:256858
Biological Process	GO:0050911	detection of chemical stimulus involved in sensory perception of smell	IMP	J:237910
Biological Process	GO:0042756	drinking behavior	IMP	J:306585
Biological Process	GO:0006874	intracellular calcium ion homeostasis	ISO	J:164563
Biological Process	GO:0006874	intracellular calcium ion homeostasis	IBA	J:265628
Biological Process	GO:0086009	membrane repolarization	IMP	J:237910
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:72247
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:60000
Biological Process	GO:0050849	negative regulation of calcium-mediated signaling	IDA	J:306604
Biological Process	GO:0021630	olfactory nerve maturation	IMP	J:237910
Biological Process	GO:0007602	phototransduction	IMP	J:256858
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:237910
Biological Process	GO:0071805	potassium ion transmembrane transport	ISO	J:164563
Biological Process	GO:0071805	potassium ion transmembrane transport	ISA	J:80562
Biological Process	GO:0006813	potassium ion transport	IEA	J:60000
Biological Process	GO:1903998	regulation of eating behavior	IMP	J:306585
Biological Process	GO:0008277	regulation of G protein-coupled receptor signaling pathway	IMP	J:306585
Biological Process	GO:0010469	regulation of signaling receptor activity	IMP	J:306585
Biological Process	GO:1990680	response to melanocyte-stimulating hormone	IMP	J:306585
Biological Process	GO:1990834	response to odorant	IMP	J:237910
Biological Process	GO:0050896	response to stimulus	IEA	J:60000
Biological Process	GO:0007608	sensory perception of smell	IMP	J:180325
Biological Process	GO:0007608	sensory perception of smell	IBA	J:265628
Biological Process	GO:0035725	sodium ion transmembrane transport	ISA	J:80562
Biological Process	GO:0035725	sodium ion transmembrane transport	ISO	J:164563
Biological Process	GO:0006814	sodium ion transport	IEA	J:60000
Biological Process	GO:0055085	transmembrane transport	IEA	J:72247