GO Annotations Graph

• Symbol: Disc1
• Name: disrupted in schizophrenia 1
• ID: MGI:2447658

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0042802	identical protein binding	IPI	J:314277
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0019894	kinesin binding	ISO	J:155856
Molecular Function	GO:0060090	molecular adaptor activity	IDA	J:143215
Molecular Function	GO:0005515	protein binding	IPI	J:273262
Molecular Function	GO:0005515	protein binding	IPI	J:154919
Molecular Function	GO:0005515	protein binding	IPI	J:163156
Molecular Function	GO:0005515	protein binding	IPI	J:147568
Molecular Function	GO:0005515	protein binding	IPI	J:147568
Molecular Function	GO:0005515	protein binding	IPI	J:245304
Molecular Function	GO:0005515	protein binding	IPI	J:143215
Molecular Function	GO:0005515	protein binding	IPI	J:167582
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0044297	cell body	ISO	J:155856
Cellular Component	GO:0090724	central region of growth cone	ISO	J:155856
Cellular Component	GO:0005813	centrosome	ISO	J:155856
Cellular Component	GO:0005813	centrosome	ISO	J:164563
Cellular Component	GO:0005813	centrosome	IBA	J:265628
Cellular Component	GO:0005813	centrosome	IMP	J:167582
Cellular Component	GO:0005813	centrosome	IDA	J:143215
Cellular Component	GO:0036064	ciliary basal body	IDA	J:179756
Cellular Component	GO:0097546	ciliary base	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0030286	dynein complex	ISO	J:155856
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:155856
Cellular Component	GO:0098982	GABA-ergic synapse	ISO	J:164563
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:164563
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:203731
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:203731
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:203731
Cellular Component	GO:0045111	intermediate filament cytoskeleton	ISO	J:164563
Cellular Component	GO:0045111	intermediate filament cytoskeleton	IBA	J:265628
Cellular Component	GO:0005871	kinesin complex	ISO	J:155856
Cellular Component	GO:0005874	microtubule	ISO	J:155856
Cellular Component	GO:0005874	microtubule	IBA	J:265628
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	IBA	J:265628
Cellular Component	GO:0005739	mitochondrion	ISO	J:73065
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Cellular Component	GO:0014069	postsynaptic density	ISO	J:164563
Cellular Component	GO:0014069	postsynaptic density	IDA	J:143215
Cellular Component	GO:0098793	presynapse	ISO	J:164563
Cellular Component	GO:0045202	synapse	IEA	J:60000
Cellular Component	GO:0008021	synaptic vesicle	IDA	J:143215
Biological Process	GO:0060070	canonical Wnt signaling pathway	IMP	J:163156
Biological Process	GO:0021846	cell proliferation in forebrain	IMP	J:163156
Biological Process	GO:0021799	cerebral cortex radially oriented cell migration	IMP	J:163156
Biological Process	GO:0060271	cilium assembly	ISO	J:155856
Biological Process	GO:0060271	cilium assembly	IBA	J:265628
Biological Process	GO:0000226	microtubule cytoskeleton organization	ISO	J:164563
Biological Process	GO:0051560	mitochondrial calcium ion homeostasis	IMP	J:165399
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0032091	negative regulation of protein binding	IDA	J:243475
Biological Process	GO:0007399	nervous system development	ISO	J:155856
Biological Process	GO:0070050	neuron cellular homeostasis	IMP	J:165399
Biological Process	GO:0001764	neuron migration	ISO	J:164563
Biological Process	GO:0001764	neuron migration	IMP	J:151421
Biological Process	GO:0001764	neuron migration	IBA	J:265628
Biological Process	GO:0001764	neuron migration	IMP	J:220804
Biological Process	GO:0001764	neuron migration	IMP	J:171976
Biological Process	GO:0001764	neuron migration	IGI	J:220804
Biological Process	GO:1905515	non-motile cilium assembly	ISO	J:164563
Biological Process	GO:1905515	non-motile cilium assembly	IMP	J:220450
Biological Process	GO:0045773	positive regulation of axon extension	ISO	J:155856
Biological Process	GO:0001954	positive regulation of cell-matrix adhesion	ISO	J:155856
Biological Process	GO:0002052	positive regulation of neuroblast proliferation	ISO	J:164563
Biological Process	GO:0002052	positive regulation of neuroblast proliferation	IMP	J:147568
Biological Process	GO:0010976	positive regulation of neuron projection development	ISO	J:155856
Biological Process	GO:2000060	positive regulation of ubiquitin-dependent protein catabolic process	IMP	J:165399
Biological Process	GO:0030177	positive regulation of Wnt signaling pathway	IMP	J:163156
Biological Process	GO:0030177	positive regulation of Wnt signaling pathway	IMP	J:147568
Biological Process	GO:0030177	positive regulation of Wnt signaling pathway	ISO	J:164563
Biological Process	GO:0008104	protein localization	IDA	J:167582
Biological Process	GO:0071539	protein localization to centrosome	ISO	J:155856
Biological Process	GO:0021852	pyramidal neuron migration to cerebral cortex	ISO	J:155856
Biological Process	GO:0060998	regulation of dendritic spine development	ISO	J:155856
Biological Process	GO:0010975	regulation of neuron projection development	ISO	J:155856
Biological Process	GO:0010975	regulation of neuron projection development	IMP	J:154919
Biological Process	GO:0010975	regulation of neuron projection development	IMP	J:159140
Biological Process	GO:0099175	regulation of postsynapse organization	IDA	J:203731
Biological Process	GO:0099175	regulation of postsynapse organization	IMP	J:203731
Biological Process	GO:0099175	regulation of postsynapse organization	IDA	J:203731
Biological Process	GO:0090128	regulation of synapse maturation	IMP	J:159140
Biological Process	GO:0051966	regulation of synaptic transmission, glutamatergic	ISO	J:73065
Biological Process	GO:0031929	TOR signaling	IMP	J:154919
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	IMP	J:165399
Biological Process	GO:0016055	Wnt signaling pathway	IEA	J:60000