GO Annotations Graph

• Symbol: Nox1
• Name: NADPH oxidase 1
• ID: MGI:2450016

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0016174	NAD(P)H oxidase H2O2-forming activity	ISO	J:155856
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:72247
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:60000
Molecular Function	GO:0031267	small GTPase binding	ISO	J:164563
Molecular Function	GO:0016175	superoxide-generating NAD(P)H oxidase activity	ISO	J:164563
Molecular Function	GO:0016175	superoxide-generating NAD(P)H oxidase activity	IBA	J:265628
Molecular Function	GO:0016175	superoxide-generating NAD(P)H oxidase activity	IMP	J:136643
Cellular Component	GO:0030054	cell junction	IEA	J:60000
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	IDA	J:151729
Cellular Component	GO:0005769	early endosome	ISO	J:164563
Cellular Component	GO:0005768	endosome	IMP	J:136643
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0043020	NADPH oxidase complex	ISO	J:155856
Cellular Component	GO:0043020	NADPH oxidase complex	ISO	J:164563
Cellular Component	GO:0043020	NADPH oxidase complex	IBA	J:265628
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Biological Process	GO:0001525	angiogenesis	ISO	J:164563
Biological Process	GO:0016477	cell migration	ISO	J:164563
Biological Process	GO:0071455	cellular response to hyperoxia	IMP	J:167959
Biological Process	GO:0071455	cellular response to hyperoxia	IMP	J:167959
Biological Process	GO:1990451	cellular stress response to acidic pH	ISO	J:164563
Biological Process	GO:0006952	defense response	IBA	J:265628
Biological Process	GO:0030198	extracellular matrix organization	IMP	J:105425
Biological Process	GO:0042743	hydrogen peroxide metabolic process	ISO	J:164563
Biological Process	GO:0051454	intracellular pH elevation	ISO	J:164563
Biological Process	GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress	IMP	J:167959
Biological Process	GO:0007254	JNK cascade	IMP	J:167959
Biological Process	GO:0007254	JNK cascade	IMP	J:167959
Biological Process	GO:0000165	MAPK cascade	IMP	J:167959
Biological Process	GO:0000165	MAPK cascade	IMP	J:167959
Biological Process	GO:0000165	MAPK cascade	IMP	J:167959
Biological Process	GO:0072592	oxygen metabolic process	IMP	J:105425
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0045726	positive regulation of integrin biosynthetic process	ISO	J:164563
Biological Process	GO:0046330	positive regulation of JNK cascade	IMP	J:167959
Biological Process	GO:0043410	positive regulation of MAPK cascade	IMP	J:167959
Biological Process	GO:1902177	positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	IMP	J:167959
Biological Process	GO:2000379	positive regulation of reactive oxygen species metabolic process	ISO	J:155856
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	ISO	J:155856
Biological Process	GO:0003081	regulation of systemic arterial blood pressure by renin-angiotensin	IMP	J:105425
Biological Process	GO:0000302	response to reactive oxygen species	ISO	J:155856
Biological Process	GO:0007165	signal transduction	ISO	J:155856
Biological Process	GO:0042554	superoxide anion generation	ISO	J:164563
Biological Process	GO:0042554	superoxide anion generation	ISO	J:155856
Biological Process	GO:0042554	superoxide anion generation	IBA	J:265628
Biological Process	GO:0042554	superoxide anion generation	IMP	J:136643