GO Annotations Graph

• Symbol: Pde5a
• Name: phosphodiesterase 5A, cGMP-specific
• ID: MGI:2651499

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity	ISO	J:164563
Molecular Function	GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity	ISO	J:155856
Molecular Function	GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity	IBA	J:265628
Molecular Function	GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	IMP	J:153189
Molecular Function	GO:0003824	catalytic activity	IEA	J:60000
Molecular Function	GO:0030553	cGMP binding	IDA	J:139897
Molecular Function	GO:0030553	cGMP binding	IDA	J:82087
Molecular Function	GO:0004112	cyclic-nucleotide phosphodiesterase activity	IDA	J:82087
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0008081	phosphoric diester hydrolase activity	IEA	J:72247
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Biological Process	GO:0046069	cGMP catabolic process	IDA	J:82087
Biological Process	GO:0046068	cGMP metabolic process	IMP	J:153189
Biological Process	GO:0046068	cGMP metabolic process	IMP	J:164532
Biological Process	GO:0008152	metabolic process	IEA	J:60000
Biological Process	GO:0055118	negative regulation of cardiac muscle contraction	IMP	J:146192
Biological Process	GO:0042130	negative regulation of T cell proliferation	IMP	J:124590
Biological Process	GO:0048599	oocyte development	IMP	J:153189
Biological Process	GO:0048599	oocyte development	IGI	J:153189
Biological Process	GO:0048599	oocyte development	IGI	J:153189
Biological Process	GO:0048599	oocyte development	IMP	J:153189
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0010613	positive regulation of cardiac muscle hypertrophy	IMP	J:146192
Biological Process	GO:0002678	positive regulation of chronic inflammatory response	ISO	J:155856
Biological Process	GO:0045745	positive regulation of G protein-coupled receptor signaling pathway	IC	J:146192
Biological Process	GO:0043406	positive regulation of MAP kinase activity	IMP	J:146192
Biological Process	GO:0060282	positive regulation of oocyte development	IGI	J:153189
Biological Process	GO:0060282	positive regulation of oocyte development	IMP	J:153189
Biological Process	GO:0045907	positive regulation of vasoconstriction	ISO	J:155856
Biological Process	GO:0010749	regulation of nitric oxide mediated signal transduction	IGI	J:101420
Biological Process	GO:0002026	regulation of the force of heart contraction	ISO	J:155856
Biological Process	GO:0055119	relaxation of cardiac muscle	IMP	J:146192
Biological Process	GO:0007614	short-term memory	ISO	J:155856
Biological Process	GO:0007165	signal transduction	IEA	J:72247
Biological Process	GO:0042098	T cell proliferation	IMP	J:124590