GO Annotations Graph

• Symbol: Sesn2
• Name: sestrin 2
• ID: MGI:2651874

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005092	GDP-dissociation inhibitor activity	IDA	J:214946
Molecular Function	GO:0070728	leucine binding	ISO	J:164563
Molecular Function	GO:0070728	leucine binding	IBA	J:265628
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:60000
Molecular Function	GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	IBA	J:265628
Molecular Function	GO:0004601	peroxidase activity	ISO	J:164563
Molecular Function	GO:0042731	PH domain binding	IPI	J:285299
Molecular Function	GO:0005515	protein binding	IPI	J:139563
Molecular Function	GO:0005515	protein binding	IPI	J:214946
Molecular Function	GO:0140311	protein sequestering activity	ISO	J:164563
Cellular Component	GO:1990316	Atg1/ULK1 kinase complex	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0061700	GATOR2 complex	ISO	J:285299
Cellular Component	GO:0031588	nucleotide-activated protein kinase complex	IDA	J:139563
Cellular Component	GO:0005634	nucleus	IEA	J:72247
Cellular Component	GO:0031932	TORC2 complex	IDA	J:232620
Biological Process	GO:0032147	activation of protein kinase activity	IDA	J:285299
Biological Process	GO:0034198	cellular response to amino acid starvation	ISO	J:164563
Biological Process	GO:0071230	cellular response to amino acid stimulus	ISO	J:164563
Biological Process	GO:0071230	cellular response to amino acid stimulus	IMP	J:214946
Biological Process	GO:0042149	cellular response to glucose starvation	ISO	J:164563
Biological Process	GO:0071233	cellular response to leucine	ISO	J:164563
Biological Process	GO:0071233	cellular response to leucine	IBA	J:265628
Biological Process	GO:1990253	cellular response to leucine starvation	ISO	J:164563
Biological Process	GO:1990253	cellular response to leucine starvation	IBA	J:265628
Biological Process	GO:0034599	cellular response to oxidative stress	IMP	J:195093
Biological Process	GO:0030330	DNA damage response, signal transduction by p53 class mediator	ISO	J:164563
Biological Process	GO:0030330	DNA damage response, signal transduction by p53 class mediator	IMP	J:139563
Biological Process	GO:0006635	fatty acid beta-oxidation	IGI	J:189021
Biological Process	GO:0042593	glucose homeostasis	IGI	J:189021
Biological Process	GO:0046323	glucose import	IMP	J:189021
Biological Process	GO:0032042	mitochondrial DNA metabolic process	IMP	J:189021
Biological Process	GO:0007005	mitochondrion organization	IMP	J:189021
Biological Process	GO:0030308	negative regulation of cell growth	IDA	J:233574
Biological Process	GO:1904262	negative regulation of TORC1 signaling	ISO	J:164563
Biological Process	GO:1904262	negative regulation of TORC1 signaling	IMP	J:214946
Biological Process	GO:1904262	negative regulation of TORC1 signaling	IMP	J:224583
Biological Process	GO:1904262	negative regulation of TORC1 signaling	IBA	J:265628
Biological Process	GO:1902010	negative regulation of translation in response to endoplasmic reticulum stress	ISO	J:164563
Biological Process	GO:1902010	negative regulation of translation in response to endoplasmic reticulum stress	IMP	J:224583
Biological Process	GO:1904504	positive regulation of lipophagy	IMP	J:189021
Biological Process	GO:0016239	positive regulation of macroautophagy	ISO	J:164563
Biological Process	GO:0016239	positive regulation of macroautophagy	IBA	J:265628
Biological Process	GO:1900182	positive regulation of protein localization to nucleus	ISO	J:164563
Biological Process	GO:1904263	positive regulation of TORC1 signaling	ISO	J:164563
Biological Process	GO:0043491	protein kinase B signaling	IMP	J:189021
Biological Process	GO:0072659	protein localization to plasma membrane	ISO	J:285299
Biological Process	GO:0072593	reactive oxygen species metabolic process	ISO	J:164563
Biological Process	GO:2000479	regulation of cAMP-dependent protein kinase activity	IMP	J:189021
Biological Process	GO:0006111	regulation of gluconeogenesis	IMP	J:189021
Biological Process	GO:0001932	regulation of protein phosphorylation	ISO	J:164563
Biological Process	GO:0001932	regulation of protein phosphorylation	IMP	J:189021
Biological Process	GO:1901031	regulation of response to reactive oxygen species	IEA	J:72247
Biological Process	GO:0009749	response to glucose	IGI	J:189021
Biological Process	GO:0009749	response to glucose	IMP	J:189021
Biological Process	GO:0009749	response to glucose	IGI	J:189021
Biological Process	GO:0032868	response to insulin	IGI	J:189021
Biological Process	GO:0032868	response to insulin	IGI	J:189021
Biological Process	GO:0032868	response to insulin	IMP	J:189021
Biological Process	GO:0038203	TORC2 signaling	ISO	J:285299
Biological Process	GO:0070328	triglyceride homeostasis	IMP	J:189021