GO Annotations Graph

• Symbol: Lrrc8a
• Name: leucine rich repeat containing 8A VRAC subunit A
• ID: MGI:2652847

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0140360	cyclic-GMP-AMP transmembrane transporter activity	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0005253	monoatomic anion channel activity	ISO	J:164563
Molecular Function	GO:0005225	volume-sensitive anion channel activity	ISO	J:164563
Molecular Function	GO:0005225	volume-sensitive anion channel activity	ISO	J:155856
Cellular Component	GO:0009986	cell surface	ISO	J:73065
Cellular Component	GO:0005765	lysosomal membrane	ISO	J:164563
Cellular Component	GO:0005764	lysosome	IEA	J:60000
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0034702	monoatomic ion channel complex	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Biological Process	GO:0015810	aspartate transmembrane transport	ISO	J:155856
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0006884	cell volume homeostasis	ISO	J:164563
Biological Process	GO:1902476	chloride transmembrane transport	ISO	J:164563
Biological Process	GO:0140361	cyclic-GMP-AMP transmembrane import across plasma membrane	ISO	J:164563
Biological Process	GO:0098656	monoatomic anion transmembrane transport	ISO	J:164563
Biological Process	GO:0006820	monoatomic anion transport	ISO	J:164563
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:60000
Biological Process	GO:0034214	protein hexamerization	ISO	J:164563
Biological Process	GO:0006970	response to osmotic stress	ISO	J:164563
Biological Process	GO:0006970	response to osmotic stress	ISO	J:155856
Biological Process	GO:0007283	spermatogenesis	IEA	J:60000
Biological Process	GO:0015734	taurine transport	ISO	J:155856