GO Annotations Graph

• Symbol: Acvr1c
• Name: activin A receptor, type IC
• ID: MGI:2661081

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0048185	activin binding	ISO	J:73065
Molecular Function	GO:0016361	activin receptor activity, type I	ISO	J:155856
Molecular Function	GO:0016361	activin receptor activity, type I	ISO	J:164563
Molecular Function	GO:0016361	activin receptor activity, type I	IBA	J:265628
Molecular Function	GO:0005524	ATP binding	ISO	J:155856
Molecular Function	GO:0070700	BMP receptor binding	ISO	J:155856
Molecular Function	GO:0019838	growth factor binding	ISO	J:164563
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0038100	nodal binding	ISO	J:164563
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0004672	protein kinase activity	IEA	J:72247
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:155856
Molecular Function	GO:0046332	SMAD binding	ISO	J:155856
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0004675	transmembrane receptor protein serine/threonine kinase activity	IEA	J:72245
Molecular Function	GO:0004675	transmembrane receptor protein serine/threonine kinase activity	IEA	J:72247
Cellular Component	GO:0048179	activin receptor complex	ISO	J:164563
Cellular Component	GO:0048179	activin receptor complex	ISO	J:155856
Cellular Component	GO:0048179	activin receptor complex	IBA	J:265628
Cellular Component	GO:0009986	cell surface	ISO	J:155856
Cellular Component	GO:0009986	cell surface	ISO	J:73065
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-1225898
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-2470487
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-2470495
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Biological Process	GO:0032924	activin receptor signaling pathway	IBA	J:265628
Biological Process	GO:0030262	apoptotic nuclear changes	ISO	J:164563
Biological Process	GO:0006915	apoptotic process	IEA	J:60000
Biological Process	GO:0030154	cell differentiation	ISO	J:155856
Biological Process	GO:0030154	cell differentiation	ISO	J:164563
Biological Process	GO:0071363	cellular response to growth factor stimulus	IBA	J:265628
Biological Process	GO:0030073	insulin secretion	IMP	J:136342
Biological Process	GO:0019915	lipid storage	IMP	J:136342
Biological Process	GO:1901383	negative regulation of chorionic trophoblast cell proliferation	ISO	J:164563
Biological Process	GO:0046676	negative regulation of insulin secretion	IMP	J:136342
Biological Process	GO:1901164	negative regulation of trophoblast cell migration	ISO	J:164563
Biological Process	GO:0007399	nervous system development	IBA	J:265628
Biological Process	GO:0038092	nodal signaling pathway	ISO	J:164563
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:73065
Biological Process	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	ISO	J:155856
Biological Process	GO:0006468	protein phosphorylation	IBA	J:265628
Biological Process	GO:0042981	regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0002021	response to dietary excess	IMP	J:136322
Biological Process	GO:0009749	response to glucose	IMP	J:136342
Biological Process	GO:0032868	response to insulin	IMP	J:136322
Biological Process	GO:0007181	transforming growth factor beta receptor complex assembly	ISO	J:155856
Biological Process	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	IEA	J:72247
Biological Process	GO:0001834	trophectodermal cell proliferation	ISO	J:73065