GO Annotations Graph

• Symbol: Synm
• Name: synemin, intermediate filament protein
• ID: MGI:2661187

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0019215	intermediate filament binding	IDA	J:92830
Molecular Function	GO:0019215	intermediate filament binding	IBA	J:265628
Molecular Function	GO:0005515	protein binding	IPI	J:122062
Molecular Function	GO:0005515	protein binding	IPI	J:216948
Molecular Function	GO:0030674	protein-macromolecule adaptor activity	ISO	J:73065
Molecular Function	GO:0005200	structural constituent of cytoskeleton	ISO	J:164563
Molecular Function	GO:0005200	structural constituent of cytoskeleton	IBA	J:265628
Molecular Function	GO:0008307	structural constituent of muscle	ISO	J:164563
Molecular Function	GO:0008307	structural constituent of muscle	IBA	J:265628
Molecular Function	GO:0017166	vinculin binding	ISO	J:164563
Molecular Function	GO:0017166	vinculin binding	IBA	J:265628
Cellular Component	GO:0030054	cell junction	IEA	J:60000
Cellular Component	GO:0043034	costamere	ISO	J:164563
Cellular Component	GO:0043034	costamere	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0005882	intermediate filament	ISO	J:155856
Cellular Component	GO:0005882	intermediate filament	ISO	J:164563
Cellular Component	GO:0005882	intermediate filament	IBA	J:265628
Cellular Component	GO:0005882	intermediate filament	ISO	J:73065
Cellular Component	GO:0045111	intermediate filament cytoskeleton	ISO	J:164563
Cellular Component	GO:0016020	membrane	IDA	J:113326
Cellular Component	GO:0060053	neurofilament cytoskeleton	IBA	J:265628
Cellular Component	GO:0060053	neurofilament cytoskeleton	IDA	J:113326
Cellular Component	GO:0042383	sarcolemma	IBA	J:265628
Cellular Component	GO:0042383	sarcolemma	IDA	J:224030
Cellular Component	GO:0030018	Z disc	ISO	J:73065
Biological Process	GO:0031443	fast-twitch skeletal muscle fiber contraction	IBA	J:265628
Biological Process	GO:0031443	fast-twitch skeletal muscle fiber contraction	IMP	J:224030
Biological Process	GO:0045104	intermediate filament cytoskeleton organization	IEA	J:72247