GO Annotations Graph

• Symbol: P2rx2
• Name: purinergic receptor P2X, ligand-gated ion channel, 2
• ID: MGI:2665170

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	ISO	J:155856
Molecular Function	GO:0046870	cadmium ion binding	ISO	J:155856
Molecular Function	GO:0050897	cobalt ion binding	ISO	J:155856
Molecular Function	GO:0005507	copper ion binding	ISO	J:155856
Molecular Function	GO:0004931	extracellularly ATP-gated monoatomic cation channel activity	ISO	J:155856
Molecular Function	GO:0004931	extracellularly ATP-gated monoatomic cation channel activity	ISO	J:164563
Molecular Function	GO:0004931	extracellularly ATP-gated monoatomic cation channel activity	IBA	J:265628
Molecular Function	GO:0004931	extracellularly ATP-gated monoatomic cation channel activity	IMP	J:97222
Molecular Function	GO:0004931	extracellularly ATP-gated monoatomic cation channel activity	IGI	J:97222
Molecular Function	GO:0004931	extracellularly ATP-gated monoatomic cation channel activity	IDA	J:88199
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0015276	ligand-gated monoatomic ion channel activity	ISO	J:155856
Molecular Function	GO:0045340	mercury ion binding	ISO	J:155856
Molecular Function	GO:0005216	monoatomic ion channel activity	IEA	J:72247
Molecular Function	GO:0016151	nickel cation binding	ISO	J:155856
Molecular Function	GO:0035091	phosphatidylinositol binding	ISO	J:155856
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0001614	purinergic nucleotide receptor activity	ISO	J:155856
Molecular Function	GO:0043924	suramin binding	ISO	J:155856
Molecular Function	GO:0008270	zinc ion binding	ISO	J:155856
Cellular Component	GO:0016324	apical plasma membrane	ISO	J:164563
Cellular Component	GO:0009986	cell surface	ISO	J:155856
Cellular Component	GO:0043197	dendritic spine	ISO	J:155856
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0005622	intracellular anatomical structure	IDA	J:112498
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0098992	neuronal dense core vesicle	IDA	J:326640
Cellular Component	GO:0098992	neuronal dense core vesicle	IDA	J:326640
Cellular Component	GO:0098992	neuronal dense core vesicle	IDA	J:326640
Cellular Component	GO:0098992	neuronal dense core vesicle	EXP	J:326640
Cellular Component	GO:0098992	neuronal dense core vesicle	IDA	J:326640
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IDA	J:128394
Cellular Component	GO:0014069	postsynaptic density	ISO	J:155856
Cellular Component	GO:0048787	presynaptic active zone membrane	ISO	J:155856
Cellular Component	GO:0042734	presynaptic membrane	ISO	J:155856
Cellular Component	GO:0043235	receptor complex	ISO	J:164563
Cellular Component	GO:0043235	receptor complex	ISO	J:155856
Cellular Component	GO:0043235	receptor complex	ISO	J:194542
Cellular Component	GO:0043195	terminal bouton	ISO	J:155856
Biological Process	GO:0048266	behavioral response to pain	IMP	J:112498
Biological Process	GO:0048266	behavioral response to pain	IGI	J:112498
Biological Process	GO:0007268	chemical synaptic transmission	IMP	J:88199
Biological Process	GO:0003029	detection of hypoxic conditions in blood by carotid body chemoreceptor signaling	IMP	J:86890
Biological Process	GO:0098655	monoatomic cation transmembrane transport	IEA	J:72247
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:60000
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:72247
Biological Process	GO:0007528	neuromuscular junction development	IMP	J:128394
Biological Process	GO:0007274	neuromuscular synaptic transmission	IMP	J:105504
Biological Process	GO:0007274	neuromuscular synaptic transmission	IMP	J:105504
Biological Process	GO:0019228	neuronal action potential	ISO	J:155856
Biological Process	GO:0030432	peristalsis	IMP	J:105504
Biological Process	GO:0030432	peristalsis	IMP	J:105504
Biological Process	GO:0099509	regulation of presynaptic cytosolic calcium ion concentration	ISO	J:155856
Biological Process	GO:2000300	regulation of synaptic vesicle exocytosis	ISO	J:155856
Biological Process	GO:0033198	response to ATP	IMP	J:112498
Biological Process	GO:0033198	response to ATP	IMP	J:112498
Biological Process	GO:0033198	response to ATP	IMP	J:105054
Biological Process	GO:0033198	response to ATP	IGI	J:112498
Biological Process	GO:0033198	response to ATP	IMP	J:105054
Biological Process	GO:0033198	response to ATP	IGI	J:112498
Biological Process	GO:0033198	response to ATP	IMP	J:112498
Biological Process	GO:0033198	response to ATP	IMP	J:112498
Biological Process	GO:0033198	response to ATP	IGI	J:112498
Biological Process	GO:0033198	response to ATP	IGI	J:112498
Biological Process	GO:0009743	response to carbohydrate	IMP	J:103231
Biological Process	GO:0001666	response to hypoxia	IMP	J:86890
Biological Process	GO:0002931	response to ischemia	ISO	J:155856
Biological Process	GO:0014070	response to organic cyclic compound	ISO	J:155856
Biological Process	GO:0010033	response to organic substance	IMP	J:105504
Biological Process	GO:0007605	sensory perception of sound	IMP	J:194332
Biological Process	GO:0007605	sensory perception of sound	ISO	J:164563
Biological Process	GO:0050909	sensory perception of taste	IGI	J:103231
Biological Process	GO:0048741	skeletal muscle fiber development	IMP	J:128394
Biological Process	GO:0014832	urinary bladder smooth muscle contraction	IMP	J:112498
Biological Process	GO:0014832	urinary bladder smooth muscle contraction	IGI	J:112498