GO Annotations Graph

• Symbol: Shank2
• Name: SH3 and multiple ankyrin repeat domains 2
• ID: MGI:2671987

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0035255	ionotropic glutamate receptor binding	IPI	J:150922
Molecular Function	GO:0035255	ionotropic glutamate receptor binding	IPI	J:108736
Molecular Function	GO:0035255	ionotropic glutamate receptor binding	IBA	J:265628
Molecular Function	GO:0017124	SH3 domain binding	ISO	J:155856
Molecular Function	GO:0098919	structural constituent of postsynaptic density	ISO	J:155856
Molecular Function	GO:0030160	synaptic receptor adaptor activity	IBA	J:265628
Cellular Component	GO:0016324	apical plasma membrane	ISO	J:155856
Cellular Component	GO:0032279	asymmetric synapse	ISO	J:155856
Cellular Component	GO:0031526	brush border membrane	ISO	J:155856
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0060170	ciliary membrane	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0043197	dendritic spine	IDA	J:150922
Cellular Component	GO:0043197	dendritic spine	IDA	J:150922
Cellular Component	GO:0043197	dendritic spine	IBA	J:265628
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0030426	growth cone	ISO	J:155856
Cellular Component	GO:0098686	hippocampal mossy fiber to CA3 synapse	ISO	J:155856
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005883	neurofilament	IDA	J:180567
Cellular Component	GO:0005883	neurofilament	IDA	J:180567
Cellular Component	GO:0043005	neuron projection	IDA	J:184110
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0001917	photoreceptor inner segment	IDA	J:180567
Cellular Component	GO:0001917	photoreceptor inner segment	IDA	J:180567
Cellular Component	GO:0001750	photoreceptor outer segment	IDA	J:180567
Cellular Component	GO:0001750	photoreceptor outer segment	IDA	J:180567
Cellular Component	GO:0005886	plasma membrane	IDA	J:150922
Cellular Component	GO:0005886	plasma membrane	IDA	J:150922
Cellular Component	GO:0014069	postsynaptic density	ISO	J:155856
Cellular Component	GO:0014069	postsynaptic density	ISO	J:155856
Cellular Component	GO:0014069	postsynaptic density	IBA	J:265628
Cellular Component	GO:0045211	postsynaptic membrane	IDA	J:150922
Cellular Component	GO:0045211	postsynaptic membrane	IBA	J:265628
Cellular Component	GO:0048786	presynaptic active zone	ISO	J:168713
Cellular Component	GO:0045202	synapse	IEA	J:60000
Biological Process	GO:0030534	adult behavior	ISO	J:164563
Biological Process	GO:0030534	adult behavior	IMP	J:186718
Biological Process	GO:0008344	adult locomotory behavior	ISO	J:155856
Biological Process	GO:0008306	associative learning	ISO	J:155856
Biological Process	GO:0035640	exploration behavior	IMP	J:186718
Biological Process	GO:0007612	learning	IMP	J:186718
Biological Process	GO:0007612	learning	ISO	J:164563
Biological Process	GO:0060292	long-term synaptic depression	IMP	J:186718
Biological Process	GO:0060291	long-term synaptic potentiation	IMP	J:186718
Biological Process	GO:0007613	memory	IMP	J:186718
Biological Process	GO:0035331	negative regulation of hippo signaling	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0051968	positive regulation of synaptic transmission, glutamatergic	IMP	J:186719
Biological Process	GO:0099175	regulation of postsynapse organization	ISO	J:155856
Biological Process	GO:0009410	response to xenobiotic stimulus	ISO	J:155856
Biological Process	GO:0035176	social behavior	IMP	J:186718
Biological Process	GO:0035176	social behavior	ISO	J:155856
Biological Process	GO:0035176	social behavior	ISO	J:164563
Biological Process	GO:0007416	synapse assembly	IMP	J:186718
Biological Process	GO:0071625	vocalization behavior	ISO	J:164563
Biological Process	GO:0071625	vocalization behavior	IMP	J:186718