GO Annotations Graph

• Symbol: Abca12
• Name: ATP-binding cassette, sub-family A member 12
• ID: MGI:2676312

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0140359	ABC-type transporter activity	IEA	J:72247
Molecular Function	GO:0034191	apolipoprotein A-I receptor binding	ISO	J:164563
Molecular Function	GO:0034191	apolipoprotein A-I receptor binding	IBA	J:265628
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0140326	ATPase-coupled intramembrane lipid transporter activity	IEA	J:72245
Molecular Function	GO:0042626	ATPase-coupled transmembrane transporter activity	IBA	J:265628
Molecular Function	GO:0005319	lipid transporter activity	ISO	J:164563
Molecular Function	GO:0005319	lipid transporter activity	IBA	J:265628
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:200990
Molecular Function	GO:0005515	protein binding	IPI	J:200990
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0031410	cytoplasmic vesicle	IEA	J:60000
Cellular Component	GO:0005829	cytosol	IDA	J:139048
Cellular Component	GO:0097209	epidermal lamellar body	ISO	J:164563
Cellular Component	GO:0097234	epidermal lamellar body membrane	ISO	J:164563
Cellular Component	GO:0005794	Golgi apparatus	IEA	J:60000
Cellular Component	GO:0000139	Golgi membrane	ISO	J:164563
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	IBA	J:265628
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0005743	mitochondrial inner membrane	HDA	J:100953
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Biological Process	GO:0006672	ceramide metabolic process	IMP	J:162119
Biological Process	GO:0006672	ceramide metabolic process	ISO	J:164563
Biological Process	GO:0035627	ceramide transport	IMP	J:208287
Biological Process	GO:0035627	ceramide transport	ISO	J:164563
Biological Process	GO:0035627	ceramide transport	IMP	J:262458
Biological Process	GO:0035627	ceramide transport	IMP	J:162119
Biological Process	GO:0035627	ceramide transport	IMP	J:144062
Biological Process	GO:0033344	cholesterol efflux	IMP	J:200990
Biological Process	GO:0003336	corneocyte desquamation	ISO	J:164563
Biological Process	GO:0003336	corneocyte desquamation	IMP	J:262458
Biological Process	GO:0051649	establishment of localization in cell	IMP	J:200990
Biological Process	GO:0061436	establishment of skin barrier	IMP	J:162119
Biological Process	GO:0061436	establishment of skin barrier	IMP	J:262458
Biological Process	GO:0061436	establishment of skin barrier	IMP	J:144062
Biological Process	GO:0061436	establishment of skin barrier	IMP	J:139048
Biological Process	GO:0061436	establishment of skin barrier	IMP	J:161652
Biological Process	GO:0006886	intracellular protein transport	ISO	J:164563
Biological Process	GO:0031424	keratinization	IMP	J:161652
Biological Process	GO:0031424	keratinization	IMP	J:139048
Biological Process	GO:0031424	keratinization	IMP	J:144062
Biological Process	GO:0030216	keratinocyte differentiation	IMP	J:161652
Biological Process	GO:0055088	lipid homeostasis	IMP	J:161652
Biological Process	GO:0006869	lipid transport	ISO	J:164563
Biological Process	GO:0006869	lipid transport	IBA	J:265628
Biological Process	GO:0048286	lung alveolus development	IMP	J:139048
Biological Process	GO:0033700	phospholipid efflux	ISO	J:164563
Biological Process	GO:0010875	positive regulation of cholesterol efflux	ISO	J:164563
Biological Process	GO:0010875	positive regulation of cholesterol efflux	IMP	J:200990
Biological Process	GO:0010875	positive regulation of cholesterol efflux	IGI	J:200990
Biological Process	GO:0032379	positive regulation of intracellular lipid transport	IMP	J:262458
Biological Process	GO:2000010	positive regulation of protein localization to cell surface	IMP	J:200990
Biological Process	GO:0072659	protein localization to plasma membrane	ISO	J:164563
Biological Process	GO:0045055	regulated exocytosis	ISO	J:164563
Biological Process	GO:0061178	regulation of insulin secretion involved in cellular response to glucose stimulus	IMP	J:285784
Biological Process	GO:0045616	regulation of keratinocyte differentiation	ISO	J:164563
Biological Process	GO:0045616	regulation of keratinocyte differentiation	IMP	J:162119
Biological Process	GO:0032940	secretion by cell	ISO	J:164563
Biological Process	GO:0043129	surfactant homeostasis	IMP	J:139048
Biological Process	GO:0055085	transmembrane transport	IEA	J:72247