GO Annotations Graph

• Symbol: Akap13
• Name: A kinase anchor protein 13
• ID: MGI:2676556

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004691	cAMP-dependent protein kinase activity	IEA	J:72247
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	ISO	J:164563
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	IDA	J:231257
Molecular Function	GO:0005078	MAP-kinase scaffold activity	ISO	J:164563
Molecular Function	GO:0005078	MAP-kinase scaffold activity	ISO	J:155856
Molecular Function	GO:0005078	MAP-kinase scaffold activity	IBA	J:265628
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0060090	molecular adaptor activity	ISO	J:164563
Molecular Function	GO:0051018	protein kinase A binding	ISO	J:164563
Molecular Function	GO:0031267	small GTPase binding	ISO	J:164563
Cellular Component	GO:0015629	actin cytoskeleton	IDA	J:181087
Cellular Component	GO:0015629	actin cytoskeleton	IBA	J:265628
Cellular Component	GO:0005884	actin filament	IDA	J:181087
Cellular Component	GO:0005938	cell cortex	ISO	J:164563
Cellular Component	GO:0030864	cortical actin cytoskeleton	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005634	nucleus	IEA	J:60000
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Biological Process	GO:0086023	adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process	IMP	J:231257
Biological Process	GO:0071875	adrenergic receptor signaling pathway	ISO	J:155856
Biological Process	GO:0071875	adrenergic receptor signaling pathway	ISO	J:164563
Biological Process	GO:0071875	adrenergic receptor signaling pathway	IBA	J:265628
Biological Process	GO:0060348	bone development	IMP	J:231357
Biological Process	GO:0055007	cardiac muscle cell differentiation	IMP	J:181087
Biological Process	GO:0061049	cell growth involved in cardiac muscle cell development	ISO	J:155856
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	ISO	J:164563
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	ISO	J:155856
Biological Process	GO:0007507	heart development	IMP	J:181087
Biological Process	GO:0051168	nuclear export	ISO	J:155856
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	ISO	J:155856
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	IBA	J:265628
Biological Process	GO:0043406	positive regulation of MAP kinase activity	ISO	J:155856
Biological Process	GO:0035025	positive regulation of Rho protein signal transduction	ISO	J:164563
Biological Process	GO:1900169	regulation of glucocorticoid mediated signaling pathway	IMP	J:111574
Biological Process	GO:0035023	regulation of Rho protein signal transduction	IBA	J:265628
Biological Process	GO:0060297	regulation of sarcomere organization	IMP	J:181087