GO Annotations Graph

• Symbol: Crb2
• Name: crumbs family member 2
• ID: MGI:2679260

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0019828	aspartic-type endopeptidase inhibitor activity	ISO	J:164563
Molecular Function	GO:0005509	calcium ion binding	IEA	J:72247
Molecular Function	GO:0005515	protein binding	IPI	J:160624
Molecular Function	GO:0005515	protein binding	IPI	J:227336
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:164563
Cellular Component	GO:0045177	apical part of cell	IDA	J:220858
Cellular Component	GO:0045177	apical part of cell	IDA	J:220858
Cellular Component	GO:0045177	apical part of cell	IDA	J:220858
Cellular Component	GO:0016324	apical plasma membrane	IDA	J:296096
Cellular Component	GO:0016324	apical plasma membrane	IDA	J:238551
Cellular Component	GO:0016324	apical plasma membrane	IDA	J:160624
Cellular Component	GO:0016324	apical plasma membrane	IDA	J:227336
Cellular Component	GO:0016327	apicolateral plasma membrane	IDA	J:298908
Cellular Component	GO:0030054	cell junction	IDA	J:298908
Cellular Component	GO:0005737	cytoplasm	IDA	J:298908
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:0032991	protein-containing complex	IBA	J:265628
Cellular Component	GO:0035003	subapical complex	IDA	J:114927
Biological Process	GO:0072359	circulatory system development	IMP	J:177837
Biological Process	GO:0030010	establishment of cell polarity	IMP	J:191149
Biological Process	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity	IBA	J:265628
Biological Process	GO:0007369	gastrulation	IEA	J:60000
Biological Process	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IBA	J:265628
Biological Process	GO:0055111	ingression involved in gastrulation with mouth forming second	IMP	J:238551
Biological Process	GO:0045199	maintenance of epithelial cell apical/basal polarity	IMP	J:177837
Biological Process	GO:0001707	mesoderm formation	IMP	J:238551
Biological Process	GO:0001707	mesoderm formation	IMP	J:177837
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0010951	negative regulation of endopeptidase activity	ISO	J:164563
Biological Process	GO:0014028	notochord formation	IMP	J:177837
Biological Process	GO:0045494	photoreceptor cell maintenance	IMP	J:191149
Biological Process	GO:0030513	positive regulation of BMP signaling pathway	IMP	J:177837
Biological Process	GO:0010718	positive regulation of epithelial to mesenchymal transition	IMP	J:177837
Biological Process	GO:0010718	positive regulation of epithelial to mesenchymal transition	IMP	J:238551
Biological Process	GO:0010470	regulation of gastrulation	IMP	J:227336
Biological Process	GO:0001895	retina homeostasis	IMP	J:191149
Biological Process	GO:0046549	retinal cone cell development	IMP	J:191149
Biological Process	GO:0001756	somitogenesis	IMP	J:177837