GO Annotations Graph

• Symbol: Nploc4
• Name: NPL4 homolog, ubiquitin recognition factor
• ID: MGI:2679787

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0051117	ATPase binding	ISO	J:155856
Molecular Function	GO:0036435	K48-linked polyubiquitin modification-dependent protein binding	ISO	J:155856
Molecular Function	GO:0070530	K63-linked polyubiquitin modification-dependent protein binding	ISO	J:155856
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0043130	ubiquitin binding	ISO	J:155856
Molecular Function	GO:0043130	ubiquitin binding	IBA	J:265628
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:155856
Molecular Function	GO:0031625	ubiquitin protein ligase binding	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005783	endoplasmic reticulum	IEA	J:60000
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0036501	UFD1-NPL4 complex	ISO	J:164563
Cellular Component	GO:0036501	UFD1-NPL4 complex	ISO	J:155856
Cellular Component	GO:0034098	VCP-NPL4-UFD1 AAA ATPase complex	ISO	J:155856
Cellular Component	GO:0034098	VCP-NPL4-UFD1 AAA ATPase complex	ISO	J:164563
Cellular Component	GO:0034098	VCP-NPL4-UFD1 AAA ATPase complex	EXP	J:245245
Biological Process	GO:0007030	Golgi organization	ISO	J:155856
Biological Process	GO:0039536	negative regulation of RIG-I signaling pathway	ISO	J:164563
Biological Process	GO:0032480	negative regulation of type I interferon production	ISO	J:164563
Biological Process	GO:0030970	retrograde protein transport, ER to cytosol	EXP	J:220515
Biological Process	GO:0030970	retrograde protein transport, ER to cytosol	ISO	J:164563
Biological Process	GO:0030970	retrograde protein transport, ER to cytosol	ISO	J:155856
Biological Process	GO:0030433	ubiquitin-dependent ERAD pathway	EXP	J:220515
Biological Process	GO:0030433	ubiquitin-dependent ERAD pathway	ISO	J:155856
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	ISO	J:164563
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	IBA	J:265628