GO Annotations Graph

• Symbol: Hcrtr2
• Name: hypocretin (orexin) receptor 2
• ID: MGI:2680765

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004930	G protein-coupled receptor activity	ISO	J:155856
Molecular Function	GO:0016499	orexin receptor activity	ISO	J:164563
Molecular Function	GO:0016499	orexin receptor activity	ISO	J:155856
Molecular Function	GO:0016499	orexin receptor activity	IBA	J:265628
Molecular Function	GO:0016499	orexin receptor activity	IDA	J:93583
Molecular Function	GO:0042277	peptide binding	IBA	J:265628
Molecular Function	GO:0017046	peptide hormone binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:179764
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Biological Process	GO:0032870	cellular response to hormone stimulus	IBA	J:265628
Biological Process	GO:0022410	circadian sleep/wake cycle process	IEA	J:72247
Biological Process	GO:0007631	feeding behavior	ISO	J:155856
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	ISO	J:155856
Biological Process	GO:0040011	locomotion	IGI	J:314552
Biological Process	GO:0007218	neuropeptide signaling pathway	ISO	J:164563
Biological Process	GO:0007218	neuropeptide signaling pathway	ISO	J:155856
Biological Process	GO:0007218	neuropeptide signaling pathway	IBA	J:265628
Biological Process	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	IDA	J:93583
Biological Process	GO:0051480	regulation of cytosolic calcium ion concentration	ISO	J:164563
Biological Process	GO:0007165	signal transduction	IEA	J:60000