GO Annotations Graph

• Symbol: Npc1l1
• Name: NPC1 like intracellular cholesterol transporter 1
• ID: MGI:2685089

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0015485	cholesterol binding	ISO	J:164563
Molecular Function	GO:0015485	cholesterol binding	IBA	J:265628
Molecular Function	GO:1901363	heterocyclic compound binding	ISO	J:155856
Molecular Function	GO:0005319	lipid transporter activity	IEA	J:72247
Molecular Function	GO:0031489	myosin V binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:263730
Molecular Function	GO:0005515	protein binding	IPI	J:263730
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0031267	small GTPase binding	ISO	J:164563
Molecular Function	GO:0008431	vitamin E binding	ISO	J:164563
Cellular Component	GO:0016324	apical plasma membrane	ISO	J:155856
Cellular Component	GO:0031526	brush border membrane	ISO	J:155856
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Biological Process	GO:0071501	cellular response to sterol depletion	ISO	J:164563
Biological Process	GO:0006695	cholesterol biosynthetic process	ISO	J:164563
Biological Process	GO:0042632	cholesterol homeostasis	IBA	J:265628
Biological Process	GO:0042632	cholesterol homeostasis	IMP	J:89712
Biological Process	GO:0070508	cholesterol import	ISO	J:155856
Biological Process	GO:0008203	cholesterol metabolic process	IEA	J:60000
Biological Process	GO:0030301	cholesterol transport	IMP	J:89712
Biological Process	GO:0030301	cholesterol transport	ISO	J:164563
Biological Process	GO:0030299	intestinal cholesterol absorption	ISO	J:164563
Biological Process	GO:0030299	intestinal cholesterol absorption	IMP	J:89712
Biological Process	GO:0030299	intestinal cholesterol absorption	IBA	J:265628
Biological Process	GO:0006629	lipid metabolic process	IEA	J:60000
Biological Process	GO:0042157	lipoprotein metabolic process	ISO	J:164563
Biological Process	GO:0008202	steroid metabolic process	IEA	J:60000
Biological Process	GO:0042360	vitamin E metabolic process	ISO	J:164563
Biological Process	GO:0051180	vitamin transport	ISO	J:164563
Biological Process	GO:0051180	vitamin transport	ISO	J:155856