GO Annotations Graph

• Symbol: Akap5
• Name: A kinase anchor protein 5
• ID: MGI:2685104

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003779	actin binding	ISO	J:155856
Molecular Function	GO:0008179	adenylate cyclase binding	ISO	J:164563
Molecular Function	GO:0008179	adenylate cyclase binding	ISO	J:155856
Molecular Function	GO:0008179	adenylate cyclase binding	IBA	J:265628
Molecular Function	GO:0008179	adenylate cyclase binding	IPI	J:159250
Molecular Function	GO:0031698	beta-2 adrenergic receptor binding	ISO	J:155856
Molecular Function	GO:0031698	beta-2 adrenergic receptor binding	IBA	J:265628
Molecular Function	GO:0045296	cadherin binding	ISO	J:155856
Molecular Function	GO:0005516	calmodulin binding	IEA	J:60000
Molecular Function	GO:0005516	calmodulin binding	IEA	J:72247
Molecular Function	GO:0001664	G protein-coupled receptor binding	ISO	J:155856
Molecular Function	GO:0050811	GABA receptor binding	ISO	J:155856
Molecular Function	GO:0050811	GABA receptor binding	IBA	J:265628
Molecular Function	GO:0035254	glutamate receptor binding	ISO	J:155856
Molecular Function	GO:0035254	glutamate receptor binding	ISO	J:164563
Molecular Function	GO:0035254	glutamate receptor binding	IBA	J:265628
Molecular Function	GO:0019900	kinase binding	ISO	J:155856
Molecular Function	GO:0060090	molecular adaptor activity	ISO	J:155856
Molecular Function	GO:0060090	molecular adaptor activity	IBA	J:265628
Molecular Function	GO:0060090	molecular adaptor activity	IDA	J:328021
Molecular Function	GO:0005515	protein binding	IPI	J:119946
Molecular Function	GO:0005515	protein binding	IPI	J:190017
Molecular Function	GO:0005515	protein binding	IPI	J:266119
Molecular Function	GO:0019904	protein domain specific binding	ISO	J:155856
Molecular Function	GO:0034237	protein kinase A regulatory subunit binding	ISO	J:155856
Molecular Function	GO:0034237	protein kinase A regulatory subunit binding	ISO	J:164563
Molecular Function	GO:0034237	protein kinase A regulatory subunit binding	IBA	J:265628
Molecular Function	GO:0034237	protein kinase A regulatory subunit binding	ISO	J:177007
Molecular Function	GO:0019901	protein kinase binding	ISO	J:155856
Molecular Function	GO:0030346	protein phosphatase 2B binding	ISO	J:164563
Molecular Function	GO:0030346	protein phosphatase 2B binding	ISO	J:155856
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0097110	scaffold protein binding	ISO	J:164563
Molecular Function	GO:0097110	scaffold protein binding	ISO	J:155856
Molecular Function	GO:0017124	SH3 domain binding	ISO	J:164563
Molecular Function	GO:0017124	SH3 domain binding	ISO	J:155856
Cellular Component	GO:0032279	asymmetric synapse	ISO	J:155856
Cellular Component	GO:0016323	basolateral plasma membrane	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0009898	cytoplasmic side of plasma membrane	ISO	J:164563
Cellular Component	GO:0005856	cytoskeleton	IDA	J:159250
Cellular Component	GO:0005829	cytosol	NAS	J:320049
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0032590	dendrite membrane	ISO	J:155856
Cellular Component	GO:0032590	dendrite membrane	IBA	J:265628
Cellular Component	GO:0043198	dendritic shaft	ISO	J:155856
Cellular Component	GO:0043197	dendritic spine	ISO	J:155856
Cellular Component	GO:0043197	dendritic spine	IBA	J:265628
Cellular Component	GO:0032591	dendritic spine membrane	ISO	J:155856
Cellular Component	GO:0005768	endosome	IEA	J:60000
Cellular Component	GO:0060076	excitatory synapse	ISO	J:155856
Cellular Component	GO:0060076	excitatory synapse	IBA	J:265628
Cellular Component	GO:0031527	filopodium membrane	ISO	J:155856
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0045121	membrane raft	ISO	J:164563
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-9010658
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-9010660
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-9010662
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-9010668
Cellular Component	GO:0005886	plasma membrane	IDA	J:159250
Cellular Component	GO:0014069	postsynaptic density	ISO	J:155856
Cellular Component	GO:0014069	postsynaptic density	IBA	J:265628
Cellular Component	GO:0099092	postsynaptic density, intracellular component	ISO	J:155856
Cellular Component	GO:0098837	postsynaptic recycling endosome	ISO	J:164563
Cellular Component	GO:0098837	postsynaptic recycling endosome	IDA	J:328024
Cellular Component	GO:0008287	protein serine/threonine phosphatase complex	NAS	J:320050
Cellular Component	GO:0008287	protein serine/threonine phosphatase complex	NAS	J:320049
Cellular Component	GO:0045202	synapse	IEA	J:60000
Biological Process	GO:0007193	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	ISO	J:164563
Biological Process	GO:0036394	amylase secretion	IMP	J:159250
Biological Process	GO:0070073	clustering of voltage-gated calcium channels	IMP	J:281217
Biological Process	GO:0045163	clustering of voltage-gated potassium channels	IDA	J:281217
Biological Process	GO:0051649	establishment of localization in cell	IMP	J:159250
Biological Process	GO:0007194	negative regulation of adenylate cyclase activity	ISO	J:155856
Biological Process	GO:0007194	negative regulation of adenylate cyclase activity	ISO	J:164563
Biological Process	GO:0043271	negative regulation of monoatomic ion transport	ISO	J:155856
Biological Process	GO:0043267	negative regulation of potassium ion transport	ISO	J:155856
Biological Process	GO:0045762	positive regulation of adenylate cyclase activity	ISO	J:155856
Biological Process	GO:0045762	positive regulation of adenylate cyclase activity	IBA	J:265628
Biological Process	GO:0070886	positive regulation of calcineurin-NFAT signaling cascade	NAS	J:320049
Biological Process	GO:0070886	positive regulation of calcineurin-NFAT signaling cascade	ISO	J:155856
Biological Process	GO:1905665	positive regulation of calcium ion import across plasma membrane	NAS	J:319981
Biological Process	GO:0010524	positive regulation of calcium ion transport into cytosol	ISO	J:155856
Biological Process	GO:0050775	positive regulation of dendrite morphogenesis	ISO	J:155856
Biological Process	GO:1905751	positive regulation of endosome to plasma membrane protein transport	ISO	J:164563
Biological Process	GO:1900273	positive regulation of long-term synaptic potentiation	ISO	J:164563
Biological Process	GO:0042307	positive regulation of protein import into nucleus	ISO	J:155856
Biological Process	GO:1903078	positive regulation of protein localization to plasma membrane	ISO	J:164563
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:155856
Biological Process	GO:1901387	positive regulation of voltage-gated calcium channel activity	NAS	J:319981
Biological Process	GO:0099630	postsynaptic neurotransmitter receptor cycle	IMP	J:328024
Biological Process	GO:0032984	protein-containing complex disassembly	ISO	J:155856
Biological Process	GO:0043113	receptor clustering	IDA	J:281217
Biological Process	GO:0099149	regulation of postsynaptic neurotransmitter receptor internalization	ISO	J:155856
Biological Process	GO:0010738	regulation of protein kinase A signaling	ISO	J:164563
Biological Process	GO:0007416	synapse assembly	IMP	J:328024