GO Annotations Graph

• Symbol: Kalrn
• Name: kalirin, RhoGEF kinase
• ID: MGI:2685385

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0019899	enzyme binding	ISO	J:155856
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	ISO	J:164563
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	IBA	J:265628
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0004672	protein kinase activity	IEA	J:72247
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IEA	J:60000
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IEA	J:72245
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0019898	extrinsic component of membrane	IBA	J:265628
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0043005	neuron projection	ISO	J:155856
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Cellular Component	GO:0014069	postsynaptic density	ISO	J:155856
Cellular Component	GO:0014069	postsynaptic density	ISO	J:155856
Cellular Component	GO:0014069	postsynaptic density	IBA	J:265628
Cellular Component	GO:0098793	presynapse	ISO	J:155856
Biological Process	GO:0008344	adult locomotory behavior	IMP	J:206512
Biological Process	GO:0007411	axon guidance	IBA	J:265628
Biological Process	GO:0007409	axonogenesis	ISO	J:155856
Biological Process	GO:0007417	central nervous system development	IEA	J:72247
Biological Process	GO:0046959	habituation	IMP	J:206512
Biological Process	GO:0035556	intracellular signal transduction	ISO	J:155856
Biological Process	GO:0035556	intracellular signal transduction	IBA	J:265628
Biological Process	GO:0007595	lactation	IMP	J:206512
Biological Process	GO:0042711	maternal behavior	IMP	J:206512
Biological Process	GO:0060137	maternal process involved in parturition	IMP	J:206512
Biological Process	GO:0007613	memory	IMP	J:152011
Biological Process	GO:0098885	modification of postsynaptic actin cytoskeleton	ISO	J:155856
Biological Process	GO:0060125	negative regulation of growth hormone secretion	IMP	J:206512
Biological Process	GO:0007399	nervous system development	ISO	J:155856
Biological Process	GO:0007528	neuromuscular junction development	IMP	J:206512
Biological Process	GO:0099645	neurotransmitter receptor localization to postsynaptic specialization membrane	ISO	J:155856
Biological Process	GO:0098989	NMDA selective glutamate receptor signaling pathway	ISO	J:155856
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0061003	positive regulation of dendritic spine morphogenesis	IMP	J:152011
Biological Process	GO:0061003	positive regulation of dendritic spine morphogenesis	IMP	J:152011
Biological Process	GO:0043547	positive regulation of GTPase activity	IMP	J:152011
Biological Process	GO:0006468	protein phosphorylation	IEA	J:72247
Biological Process	GO:0050773	regulation of dendrite development	ISO	J:155856
Biological Process	GO:1905274	regulation of modification of postsynaptic actin cytoskeleton	ISO	J:155856
Biological Process	GO:0098696	regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	ISO	J:155856
Biological Process	GO:0035176	social behavior	IMP	J:152011