GO Annotations Graph

• Symbol: Carmil2
• Name: capping protein regulator and myosin 1 linker 2
• ID: MGI:2685431

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005543	phospholipid binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:205441
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:164563
Cellular Component	GO:0015629	actin cytoskeleton	ISO	J:164563
Cellular Component	GO:0031252	cell leading edge	ISO	J:164563
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0005911	cell-cell junction	IDA	J:205441
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:205441
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0008290	F-actin capping protein complex	IDA	J:205441
Cellular Component	GO:0001772	immunological synapse	IDA	J:205441
Cellular Component	GO:0045111	intermediate filament cytoskeleton	ISO	J:164563
Cellular Component	GO:0030027	lamellipodium	ISO	J:164563
Cellular Component	GO:0030027	lamellipodium	IBA	J:265628
Cellular Component	GO:0044354	macropinosome	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0001726	ruffle	ISO	J:164563
Biological Process	GO:0051639	actin filament network formation	ISO	J:164563
Biological Process	GO:0016477	cell migration	IBA	J:265628
Biological Process	GO:0045184	establishment of protein localization	IMP	J:205441
Biological Process	GO:0007163	establishment or maintenance of cell polarity	ISO	J:164563
Biological Process	GO:0061339	establishment or maintenance of monopolar cell polarity	ISO	J:164563
Biological Process	GO:0048872	homeostasis of number of cells	IMP	J:205441
Biological Process	GO:0030011	maintenance of cell polarity	IEA	J:72247
Biological Process	GO:2000813	negative regulation of barbed-end actin filament capping	ISO	J:164563
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:164563
Biological Process	GO:0090091	positive regulation of extracellular matrix disassembly	ISO	J:164563
Biological Process	GO:0032743	positive regulation of interleukin-2 production	IMP	J:205411
Biological Process	GO:0032743	positive regulation of interleukin-2 production	IMP	J:205411
Biological Process	GO:0010592	positive regulation of lamellipodium assembly	ISO	J:164563
Biological Process	GO:1902745	positive regulation of lamellipodium organization	ISO	J:164563
Biological Process	GO:0045591	positive regulation of regulatory T cell differentiation	IMP	J:205441
Biological Process	GO:0045591	positive regulation of regulatory T cell differentiation	IMP	J:205441
Biological Process	GO:1900029	positive regulation of ruffle assembly	ISO	J:164563
Biological Process	GO:0042102	positive regulation of T cell proliferation	IMP	J:205441
Biological Process	GO:0032729	positive regulation of type II interferon production	IMP	J:205441
Biological Process	GO:2000249	regulation of actin cytoskeleton reorganization	IBA	J:265628
Biological Process	GO:0034315	regulation of Arp2/3 complex-mediated actin nucleation	IBA	J:265628
Biological Process	GO:0050852	T cell receptor signaling pathway	IMP	J:205441
Biological Process	GO:0048538	thymus development	IMP	J:205441
Biological Process	GO:0044319	wound healing, spreading of cells	ISO	J:164563