GO Annotations Graph

• Symbol: Mcu
• Name: mitochondrial calcium uniporter
• ID: MGI:3026965

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005262	calcium channel activity	ISO	J:164563
Molecular Function	GO:0005262	calcium channel activity	IBA	J:265628
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:201635
Molecular Function	GO:0015292	uniporter activity	ISO	J:155856
Molecular Function	GO:0015292	uniporter activity	ISO	J:164563
Molecular Function	GO:0015292	uniporter activity	IBA	J:265628
Cellular Component	GO:0034704	calcium channel complex	ISO	J:164563
Cellular Component	GO:0034704	calcium channel complex	IDA	J:196299
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005743	mitochondrial inner membrane	ISO	J:155856
Cellular Component	GO:0005743	mitochondrial inner membrane	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	HDA	J:151002
Cellular Component	GO:1990246	uniplex complex	IBA	J:265628
Cellular Component	GO:1990246	uniplex complex	ISO	J:73065
Biological Process	GO:0090527	actin filament reorganization	ISO	J:164563
Biological Process	GO:0036444	calcium import into the mitochondrion	ISO	J:164563
Biological Process	GO:0036444	calcium import into the mitochondrion	IBA	J:265628
Biological Process	GO:0036444	calcium import into the mitochondrion	ISO	J:203542
Biological Process	GO:0070588	calcium ion transmembrane transport	IEA	J:60000
Biological Process	GO:0006816	calcium ion transport	IEA	J:60000
Biological Process	GO:0019722	calcium-mediated signaling	ISO	J:164563
Biological Process	GO:0042593	glucose homeostasis	ISO	J:164563
Biological Process	GO:0051560	mitochondrial calcium ion homeostasis	ISO	J:164563
Biological Process	GO:0051560	mitochondrial calcium ion homeostasis	ISO	J:155856
Biological Process	GO:0051560	mitochondrial calcium ion homeostasis	IBA	J:265628
Biological Process	GO:0006851	mitochondrial calcium ion transmembrane transport	ISO	J:155856
Biological Process	GO:0006851	mitochondrial calcium ion transmembrane transport	ISO	J:164563
Biological Process	GO:0006851	mitochondrial calcium ion transmembrane transport	IMP	J:174848
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:60000
Biological Process	GO:0032024	positive regulation of insulin secretion	ISO	J:164563
Biological Process	GO:0051561	positive regulation of mitochondrial calcium ion concentration	ISO	J:164563
Biological Process	GO:0051561	positive regulation of mitochondrial calcium ion concentration	IMP	J:174848
Biological Process	GO:0051561	positive regulation of mitochondrial calcium ion concentration	ISO	J:155856
Biological Process	GO:0090141	positive regulation of mitochondrial fission	ISO	J:164563
Biological Process	GO:0090023	positive regulation of neutrophil chemotaxis	ISO	J:164563
Biological Process	GO:0051259	protein complex oligomerization	ISO	J:164563