GO Annotations Graph

• Symbol: Iqgap3
• Name: IQ motif containing GTPase activating protein 3
• ID: MGI:3028642

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0051015	actin filament binding	IBA	J:265628
Molecular Function	GO:0005516	calmodulin binding	ISO	J:164563
Molecular Function	GO:0005516	calmodulin binding	IBA	J:265628
Molecular Function	GO:0005096	GTPase activator activity	IBA	J:265628
Molecular Function	GO:0070856	myosin VI light chain binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:145651
Molecular Function	GO:0031267	small GTPase binding	IPI	J:145651
Cellular Component	GO:0005938	cell cortex	IBA	J:265628
Cellular Component	GO:0005911	cell-cell junction	IDA	J:145651
Cellular Component	GO:0005737	cytoplasm	IDA	J:145651
Cellular Component	GO:0016328	lateral plasma membrane	IDA	J:145651
Biological Process	GO:0071310	cellular response to organic substance	IDA	J:145651
Biological Process	GO:0070371	ERK1 and ERK2 cascade	IMP	J:145651
Biological Process	GO:0000082	G1/S transition of mitotic cell cycle	IMP	J:145651
Biological Process	GO:0010467	gene expression	IMP	J:145651
Biological Process	GO:0033598	mammary gland epithelial cell proliferation	IMP	J:145651
Biological Process	GO:1903479	mitotic actomyosin contractile ring assembly actin filament organization	IBA	J:265628
Biological Process	GO:0010629	negative regulation of gene expression	IMP	J:145651
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:145651
Biological Process	GO:0033601	positive regulation of mammary gland epithelial cell proliferation	IMP	J:145651
Biological Process	GO:0043410	positive regulation of MAPK cascade	IMP	J:145651
Biological Process	GO:0001934	positive regulation of protein phosphorylation	IMP	J:145651
Biological Process	GO:0006468	protein phosphorylation	IMP	J:145651
Biological Process	GO:0006468	protein phosphorylation	IMP	J:145651
Biological Process	GO:0007265	Ras protein signal transduction	IMP	J:145651
Biological Process	GO:0008361	regulation of cell size	IMP	J:145651