GO Annotations Graph

• Symbol: Nlrc4
• Name: NLR family, CARD domain containing 4
• ID: MGI:3036243

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	ISO	J:164563
Molecular Function	GO:0089720	caspase binding	ISO	J:164563
Molecular Function	GO:0061133	endopeptidase activator activity	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	IPI	J:247416
Molecular Function	GO:0042802	identical protein binding	IPI	J:245327
Molecular Function	GO:0042802	identical protein binding	IPI	J:245242
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:245334
Molecular Function	GO:0005515	protein binding	IPI	J:189256
Molecular Function	GO:0005515	protein binding	IPI	J:277864
Molecular Function	GO:0005515	protein binding	IPI	J:247416
Molecular Function	GO:0005515	protein binding	IPI	J:245242
Molecular Function	GO:0005515	protein binding	IPI	J:245327
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Cellular Component	GO:0061702	canonical inflammasome complex	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	IDA	J:189256
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-844613
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0072557	IPAF inflammasome complex	IDA	J:176197
Cellular Component	GO:0072557	IPAF inflammasome complex	IDA	J:189256
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Biological Process	GO:0097202	activation of cysteine-type endopeptidase activity	ISO	J:164563
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	ISO	J:164563
Biological Process	GO:0002218	activation of innate immune response	IMP	J:112671
Biological Process	GO:0006915	apoptotic process	IEA	J:60000
Biological Process	GO:0042742	defense response to bacterium	IMP	J:112670
Biological Process	GO:0042742	defense response to bacterium	IMP	J:176197
Biological Process	GO:0042742	defense response to bacterium	IMP	J:185371
Biological Process	GO:0042742	defense response to bacterium	IMP	J:189256
Biological Process	GO:0042742	defense response to bacterium	IMP	J:112671
Biological Process	GO:0042742	defense response to bacterium	ISO	J:164563
Biological Process	GO:0042742	defense response to bacterium	IBA	J:265628
Biological Process	GO:0016045	detection of bacterium	IMP	J:189256
Biological Process	GO:0016045	detection of bacterium	ISO	J:164563
Biological Process	GO:0016045	detection of bacterium	IBA	J:265628
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0006954	inflammatory response	IMP	J:189256
Biological Process	GO:0006954	inflammatory response	IMP	J:176197
Biological Process	GO:0006954	inflammatory response	IMP	J:185371
Biological Process	GO:0006954	inflammatory response	IMP	J:112671
Biological Process	GO:0006954	inflammatory response	IMP	J:112670
Biological Process	GO:0006954	inflammatory response	IMP	J:91292
Biological Process	GO:0045087	innate immune response	IEA	J:60000
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	IMP	J:112670
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	IMP	J:112671
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	IMP	J:185371
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	ISO	J:164563
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	ISO	J:164563
Biological Process	GO:0010954	positive regulation of protein processing	ISO	J:164563
Biological Process	GO:0051260	protein homooligomerization	IDA	J:176197
Biological Process	GO:0070269	pyroptosis	IMP	J:189256
Biological Process	GO:0070269	pyroptosis	IMP	J:112671
Biological Process	GO:0070269	pyroptosis	IMP	J:112670
Biological Process	GO:0070269	pyroptosis	IMP	J:176197
Biological Process	GO:0070269	pyroptosis	IMP	J:185371
Biological Process	GO:0042981	regulation of apoptotic process	IMP	J:91292
Biological Process	GO:0043281	regulation of cysteine-type endopeptidase activity involved in apoptotic process	IMP	J:91292