GO Annotations Graph

• Symbol: Duox2
• Name: dual oxidase 2
• ID: MGI:3036280

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005509	calcium ion binding	ISO	J:164563
Molecular Function	GO:0016174	NAD(P)H oxidase H2O2-forming activity	ISO	J:164563
Molecular Function	GO:0016175	superoxide-generating NAD(P)H oxidase activity	IBA	J:265628
Cellular Component	GO:0045177	apical part of cell	ISO	J:164563
Cellular Component	GO:0031252	cell leading edge	ISO	J:164563
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0043020	NADPH oxidase complex	IBA	J:265628
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Biological Process	GO:0048855	adenohypophysis morphogenesis	IMP	J:121821
Biological Process	GO:0030282	bone mineralization	IMP	J:121821
Biological Process	GO:0019221	cytokine-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0006952	defense response	IBA	J:265628
Biological Process	GO:0009566	fertilization	IMP	J:121821
Biological Process	GO:0042445	hormone metabolic process	IMP	J:121821
Biological Process	GO:0050665	hydrogen peroxide biosynthetic process	ISO	J:164563
Biological Process	GO:0048839	inner ear development	IMP	J:121821
Biological Process	GO:0035264	multicellular organism growth	IMP	J:121821
Biological Process	GO:2000147	positive regulation of cell motility	ISO	J:164563
Biological Process	GO:0090303	positive regulation of wound healing	ISO	J:164563
Biological Process	GO:0051591	response to cAMP	ISO	J:164563
Biological Process	GO:0009615	response to virus	ISO	J:164563
Biological Process	GO:0042554	superoxide anion generation	ISO	J:164563
Biological Process	GO:0042554	superoxide anion generation	IBA	J:265628
Biological Process	GO:0030878	thyroid gland development	IMP	J:121821
Biological Process	GO:0042403	thyroid hormone metabolic process	IMP	J:121821