GO Annotations Graph

• Symbol: Macroh2a2
• Name: macroH2A.2 histone
• ID: MGI:3037658

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0031490	chromatin DNA binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	IBA	J:265628
Molecular Function	GO:0046982	protein heterodimerization activity	IEA	J:72247
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0030527	structural constituent of chromatin	IEA	J:72247
Molecular Function	GO:0000976	transcription cis-regulatory region binding	ISO	J:164563
Cellular Component	GO:0001740	Barr body	ISO	J:89037
Cellular Component	GO:0000785	chromatin	ISO	J:164563
Cellular Component	GO:0000785	chromatin	ISO	J:155856
Cellular Component	GO:0005694	chromosome	IEA	J:60000
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0000786	nucleosome	IEA	J:60000
Cellular Component	GO:0000786	nucleosome	IEA	J:72247
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Biological Process	GO:0007420	brain development	ISO	J:164563
Biological Process	GO:0006325	chromatin organization	IEA	J:60000
Biological Process	GO:0007549	dosage compensation	ISO	J:89037
Biological Process	GO:0071169	establishment of protein localization to chromatin	ISO	J:164563
Biological Process	GO:0045814	negative regulation of gene expression, epigenetic	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IGI	J:220524
Biological Process	GO:1901837	negative regulation of transcription of nucleolar large rRNA by RNA polymerase I	ISO	J:164563
Biological Process	GO:0006334	nucleosome assembly	IEA	J:72247
Biological Process	GO:0045618	positive regulation of keratinocyte differentiation	ISO	J:164563