GO Annotations Graph

• Symbol: Mtss2
• Name: MTSS I-BAR domain containing 2
• ID: MGI:3039591

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003779	actin binding	IBA	J:265628
Molecular Function	GO:0003785	actin monomer binding	IDA	J:139816
Molecular Function	GO:0005096	GTPase activator activity	ISO	J:164563
Molecular Function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	IDA	J:139816
Molecular Function	GO:0005543	phospholipid binding	IBA	J:265628
Molecular Function	GO:0031267	small GTPase binding	ISO	J:164563
Molecular Function	GO:0031267	small GTPase binding	IDA	J:139816
Cellular Component	GO:0015629	actin cytoskeleton	IBA	J:265628
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0030864	cortical actin cytoskeleton	IDA	J:139816
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0030027	lamellipodium	IDA	J:139816
Cellular Component	GO:0005886	plasma membrane	IDA	J:139816
Cellular Component	GO:0001726	ruffle	IDA	J:139816
Cellular Component	GO:0032587	ruffle membrane	ISO	J:164563
Biological Process	GO:0090630	activation of GTPase activity	ISO	J:164563
Biological Process	GO:0030031	cell projection assembly	IBA	J:265628
Biological Process	GO:0036120	cellular response to platelet-derived growth factor stimulus	ISO	J:164563
Biological Process	GO:0097581	lamellipodium organization	IMP	J:139816
Biological Process	GO:0061024	membrane organization	IBA	J:265628
Biological Process	GO:0061024	membrane organization	IDA	J:139816
Biological Process	GO:0007009	plasma membrane organization	IEA	J:72247
Biological Process	GO:0097178	ruffle assembly	IEA	J:72247