GO Annotations Graph

• Symbol: Prex1
• Name: phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
• ID: MGI:3040696

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005096	GTPase activator activity	IBA	J:265628
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	IBA	J:265628
Molecular Function	GO:0005543	phospholipid binding	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0043198	dendritic shaft	ISO	J:155856
Cellular Component	GO:0030426	growth cone	ISO	J:155856
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	IBA	J:265628
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	IGI	J:168922
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	IGI	J:168922
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	IGI	J:168922
Biological Process	GO:0035556	intracellular signal transduction	IEA	J:72247
Biological Process	GO:0030593	neutrophil chemotaxis	IGI	J:168992
Biological Process	GO:0030593	neutrophil chemotaxis	IGI	J:168992
Biological Process	GO:0045785	positive regulation of cell adhesion	IGI	J:168922
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:155856
Biological Process	GO:0043547	positive regulation of GTPase activity	IBA	J:265628
Biological Process	GO:0043547	positive regulation of GTPase activity	IGI	J:168922
Biological Process	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	IGI	J:168922
Biological Process	GO:0072593	reactive oxygen species metabolic process	IGI	J:168992
Biological Process	GO:0030833	regulation of actin filament polymerization	ISO	J:155856
Biological Process	GO:0050773	regulation of dendrite development	ISO	J:155856
Biological Process	GO:0023051	regulation of signaling	IBA	J:265628
Biological Process	GO:0030217	T cell differentiation	IGI	J:168922