GO Annotations Graph

• Symbol: Trpa1
• Name: transient receptor potential cation channel, subfamily A, member 1
• ID: MGI:3522699

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005262	calcium channel activity	IDA	J:96171
Molecular Function	GO:0005262	calcium channel activity	IDA	J:123327
Molecular Function	GO:0005262	calcium channel activity	IMP	J:135206
Molecular Function	GO:0015278	calcium-release channel activity	ISO	J:164563
Molecular Function	GO:0015267	channel activity	IDA	J:95109
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0005216	monoatomic ion channel activity	IMP	J:95109
Molecular Function	GO:0005216	monoatomic ion channel activity	IDA	J:98611
Molecular Function	GO:1990760	osmolarity-sensing monoatomic cation channel activity	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:219559
Molecular Function	GO:0097604	temperature-gated cation channel activity	ISO	J:164563
Molecular Function	GO:0005245	voltage-gated calcium channel activity	ISO	J:155856
Cellular Component	GO:0016324	apical plasma membrane	ISO	J:155856
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0016020	membrane	ISS	J:96171
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0032421	stereocilium bundle	IDA	J:98611
Cellular Component	GO:0032421	stereocilium bundle	IDA	J:95109
Biological Process	GO:0097553	calcium ion transmembrane import into cytosol	ISO	J:155856
Biological Process	GO:0070588	calcium ion transmembrane transport	ISO	J:164563
Biological Process	GO:0006816	calcium ion transport	IDA	J:123327
Biological Process	GO:0006816	calcium ion transport	IMP	J:135206
Biological Process	GO:0007166	cell surface receptor signaling pathway	IMP	J:219569
Biological Process	GO:0071244	cellular response to carbon dioxide	ISO	J:155856
Biological Process	GO:0070417	cellular response to cold	ISO	J:155856
Biological Process	GO:0034605	cellular response to heat	ISO	J:155856
Biological Process	GO:0070301	cellular response to hydrogen peroxide	ISO	J:290945
Biological Process	GO:0070301	cellular response to hydrogen peroxide	ISO	J:290945
Biological Process	GO:0071310	cellular response to organic substance	ISO	J:290945
Biological Process	GO:0071310	cellular response to organic substance	IMP	J:290945
Biological Process	GO:0071310	cellular response to organic substance	IMP	J:290945
Biological Process	GO:0071310	cellular response to organic substance	IDA	J:290945
Biological Process	GO:0050968	detection of chemical stimulus involved in sensory perception of pain	IDA	J:135245
Biological Process	GO:0050968	detection of chemical stimulus involved in sensory perception of pain	IMP	J:115886
Biological Process	GO:0050968	detection of chemical stimulus involved in sensory perception of pain	IMP	J:108343
Biological Process	GO:0050968	detection of chemical stimulus involved in sensory perception of pain	IMP	J:135695
Biological Process	GO:0050968	detection of chemical stimulus involved in sensory perception of pain	IMP	J:135206
Biological Process	GO:0050974	detection of mechanical stimulus involved in sensory perception	IMP	J:223160
Biological Process	GO:0050966	detection of mechanical stimulus involved in sensory perception of pain	IMP	J:108343
Biological Process	GO:0006874	intracellular calcium ion homeostasis	ISO	J:290945
Biological Process	GO:0006874	intracellular calcium ion homeostasis	IMP	J:290945
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:72247
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:60000
Biological Process	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	ISO	J:155856
Biological Process	GO:1903793	positive regulation of monoatomic anion transport	ISO	J:155856
Biological Process	GO:1904058	positive regulation of sensory perception of pain	ISO	J:155856
Biological Process	GO:0051289	protein homotetramerization	ISO	J:164563
Biological Process	GO:1903522	regulation of blood circulation	ISO	J:155856
Biological Process	GO:0098908	regulation of neuronal action potential	ISO	J:155856
Biological Process	GO:0009409	response to cold	IMP	J:108343
Biological Process	GO:0009409	response to cold	IDA	J:96171
Biological Process	GO:0042542	response to hydrogen peroxide	IMP	J:135206
Biological Process	GO:0014070	response to organic cyclic compound	IMP	J:219569
Biological Process	GO:0010033	response to organic substance	ISO	J:164563
Biological Process	GO:0048265	response to pain	IDA	J:135245
Biological Process	GO:0048265	response to pain	IMP	J:135695
Biological Process	GO:0048265	response to pain	IMP	J:108343
Biological Process	GO:0050896	response to stimulus	IEA	J:60000
Biological Process	GO:0009410	response to xenobiotic stimulus	IDA	J:135245
Biological Process	GO:0019233	sensory perception of pain	ISO	J:164563
Biological Process	GO:0019233	sensory perception of pain	ISO	J:155856
Biological Process	GO:0050955	thermoception	IDA	J:96171
Biological Process	GO:0055085	transmembrane transport	IEA	J:72247
Biological Process	GO:0014832	urinary bladder smooth muscle contraction	ISO	J:155856