GO Annotations Graph

• Symbol: Otulin
• Name: OTU deubiquitinase with linear linkage specificity
• ID: MGI:3577015

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004843	cysteine-type deubiquitinase activity	ISO	J:164563
Molecular Function	GO:0004843	cysteine-type deubiquitinase activity	IDA	J:236075
Molecular Function	GO:0004843	cysteine-type deubiquitinase activity	IDA	J:264084
Molecular Function	GO:0004843	cysteine-type deubiquitinase activity	IDA	J:197674
Molecular Function	GO:0004843	cysteine-type deubiquitinase activity	IBA	J:265628
Molecular Function	GO:0008234	cysteine-type peptidase activity	IMP	J:197674
Molecular Function	GO:0008234	cysteine-type peptidase activity	ISO	J:164563
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0008233	peptidase activity	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:197674
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0071797	LUBAC complex	IDA	J:197674
Biological Process	GO:0001525	angiogenesis	IEA	J:60000
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0045087	innate immune response	ISO	J:164563
Biological Process	GO:0045087	innate immune response	IBA	J:265628
Biological Process	GO:0050728	negative regulation of inflammatory response	ISO	J:164563
Biological Process	GO:0050728	negative regulation of inflammatory response	IMP	J:264084
Biological Process	GO:0050728	negative regulation of inflammatory response	IMP	J:236075
Biological Process	GO:0050728	negative regulation of inflammatory response	IBA	J:265628
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	IMP	J:236075
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	ISO	J:164563
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	IBA	J:265628
Biological Process	GO:0070431	nucleotide-binding oligomerization domain containing 2 signaling pathway	ISO	J:164563
Biological Process	GO:1990108	protein linear deubiquitination	IDA	J:236075
Biological Process	GO:1990108	protein linear deubiquitination	ISO	J:164563
Biological Process	GO:1990108	protein linear deubiquitination	IDA	J:264084
Biological Process	GO:1990108	protein linear deubiquitination	IDA	J:197674
Biological Process	GO:1990108	protein linear deubiquitination	IBA	J:265628
Biological Process	GO:0006508	proteolysis	IEA	J:60000
Biological Process	GO:0060828	regulation of canonical Wnt signaling pathway	IDA	J:197674
Biological Process	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway	IMP	J:264084
Biological Process	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway	IMP	J:236075
Biological Process	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway	IBA	J:265628
Biological Process	GO:0002040	sprouting angiogenesis	IMP	J:197674
Biological Process	GO:0016055	Wnt signaling pathway	IEA	J:60000