GO Annotations Graph

• Symbol: Agap2
• Name: ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
• ID: MGI:3580016

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	ISO	J:73065
Molecular Function	GO:0005525	GTP binding	ISO	J:73065
Molecular Function	GO:0005096	GTPase activator activity	IBA	J:265628
Molecular Function	GO:0005096	GTPase activator activity	ISO	J:73065
Molecular Function	GO:0003924	GTPase activity	IBA	J:265628
Molecular Function	GO:0003924	GTPase activity	ISO	J:73065
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0035014	phosphatidylinositol 3-kinase regulator activity	ISO	J:73065
Molecular Function	GO:0005515	protein binding	IPI	J:158376
Molecular Function	GO:0005515	protein binding	IPI	J:158376
Molecular Function	GO:0030295	protein kinase activator activity	ISO	J:155856
Molecular Function	GO:0030295	protein kinase activator activity	ISO	J:73065
Molecular Function	GO:0019901	protein kinase binding	ISO	J:155856
Molecular Function	GO:0019901	protein kinase binding	ISO	J:73065
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:73065
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0005768	endosome	ISO	J:73065
Cellular Component	GO:0009897	external side of plasma membrane	ISO	J:155856
Cellular Component	GO:0090543	Flemming body	ISO	J:164563
Cellular Component	GO:0098978	glutamatergic synapse	IEP	J:326651
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:326651
Cellular Component	GO:0098978	glutamatergic synapse	IPI	J:326651
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:326651
Cellular Component	GO:0098978	glutamatergic synapse	IPI	J:326651
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	ISO	J:73065
Cellular Component	GO:0098794	postsynapse	IDA	J:326651
Cellular Component	GO:0098794	postsynapse	IEP	J:326651
Cellular Component	GO:0098794	postsynapse	IPI	J:326651
Cellular Component	GO:0098794	postsynapse	IDA	J:326651
Cellular Component	GO:0098794	postsynapse	IPI	J:326651
Biological Process	GO:0030036	actin cytoskeleton organization	ISO	J:73065
Biological Process	GO:0090630	activation of GTPase activity	IBA	J:265628
Biological Process	GO:0006915	apoptotic process	IMP	J:158376
Biological Process	GO:1905430	cellular response to glycine	ISO	J:155856
Biological Process	GO:0016197	endosomal transport	ISO	J:73065
Biological Process	GO:1904019	epithelial cell apoptotic process	IMP	J:158376
Biological Process	GO:0060749	mammary gland alveolus development	IMP	J:158376
Biological Process	GO:0033598	mammary gland epithelial cell proliferation	IGI	J:158376
Biological Process	GO:0033598	mammary gland epithelial cell proliferation	IMP	J:158376
Biological Process	GO:0033598	mammary gland epithelial cell proliferation	IGI	J:158376
Biological Process	GO:0033598	mammary gland epithelial cell proliferation	IMP	J:158376
Biological Process	GO:0043066	negative regulation of apoptotic process	IMP	J:132344
Biological Process	GO:1904036	negative regulation of epithelial cell apoptotic process	IMP	J:158376
Biological Process	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	ISO	J:155856
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	ISO	J:155856
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	IBA	J:265628
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	ISO	J:73065
Biological Process	GO:0042177	negative regulation of protein catabolic process	ISO	J:73065
Biological Process	GO:0033601	positive regulation of mammary gland epithelial cell proliferation	IGI	J:158376
Biological Process	GO:0033601	positive regulation of mammary gland epithelial cell proliferation	IMP	J:158376
Biological Process	GO:0033601	positive regulation of mammary gland epithelial cell proliferation	IMP	J:158376
Biological Process	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	ISO	J:155856
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	ISO	J:155856
Biological Process	GO:0045860	positive regulation of protein kinase activity	ISO	J:73065
Biological Process	GO:2000010	positive regulation of protein localization to cell surface	ISO	J:155856
Biological Process	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	IMP	J:158376
Biological Process	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	IMP	J:158376
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:158376
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	IMP	J:158376
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	IMP	J:158376