GO Annotations Graph

• Symbol: Nlrp1b
• Name: NLR family, pyrin domain containing 1B
• ID: MGI:3582959

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	ISO	J:164563
Molecular Function	GO:0016887	ATP hydrolysis activity	ISO	J:164563
Molecular Function	GO:0140608	cysteine-type endopeptidase activator activity	ISO	J:164563
Molecular Function	GO:0003690	double-stranded DNA binding	ISO	J:164563
Molecular Function	GO:0003725	double-stranded RNA binding	ISO	J:164563
Molecular Function	GO:0004175	endopeptidase activity	ISO	J:164563
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0140693	molecular condensate scaffold activity	ISO	J:164563
Molecular Function	GO:0140677	molecular function activator activity	ISO	J:164563
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0038187	pattern recognition receptor activity	ISO	J:164563
Molecular Function	GO:0008233	peptidase activity	IEA	J:60000
Molecular Function	GO:0019904	protein domain specific binding	ISO	J:164563
Molecular Function	GO:0043621	protein self-association	ISO	J:164563
Molecular Function	GO:0043621	protein self-association	ISO	J:164563
Molecular Function	GO:0035591	signaling adaptor activity	ISO	J:164563
Molecular Function	GO:0030546	signaling receptor activator activity	ISO	J:164563
Cellular Component	GO:0061702	canonical inflammasome complex	ISO	J:164563
Cellular Component	GO:0061702	canonical inflammasome complex	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	NAS	J:320796
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0072558	NLRP1 inflammasome complex	ISO	J:164563
Cellular Component	GO:0072558	NLRP1 inflammasome complex	NAS	J:320796
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	ISO	J:164563
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	IBA	J:265628
Biological Process	GO:0140374	antiviral innate immune response	ISO	J:164563
Biological Process	GO:0071493	cellular response to UV-B	ISO	J:164563
Biological Process	GO:0051607	defense response to virus	ISO	J:164563
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0006954	inflammatory response	IEA	J:72247
Biological Process	GO:0006954	inflammatory response	IEA	J:60000
Biological Process	GO:0045087	innate immune response	IEA	J:60000
Biological Process	GO:0045087	innate immune response	IEA	J:72247
Biological Process	GO:0032610	interleukin-1 alpha production	IMP	J:189777
Biological Process	GO:0032611	interleukin-1 beta production	IDA	J:192547
Biological Process	GO:0032611	interleukin-1 beta production	IMP	J:189777
Biological Process	GO:0051402	neuron apoptotic process	ISO	J:164563
Biological Process	GO:1904784	NLRP1 inflammasome complex assembly	ISO	J:164563
Biological Process	GO:0002221	pattern recognition receptor signaling pathway	NAS	J:320796
Biological Process	GO:0050729	positive regulation of inflammatory response	ISO	J:164563
Biological Process	GO:0050729	positive regulation of inflammatory response	NAS	J:320796
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	NAS	J:320796
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	ISO	J:164563
Biological Process	GO:0012501	programmed cell death	IEA	J:60000
Biological Process	GO:0030163	protein catabolic process	IMP	J:192547
Biological Process	GO:0030163	protein catabolic process	IMP	J:192547
Biological Process	GO:0051260	protein homooligomerization	ISO	J:164563
Biological Process	GO:0051260	protein homooligomerization	ISO	J:164563
Biological Process	GO:0006508	proteolysis	IEA	J:60000
Biological Process	GO:0070269	pyroptosis	ISO	J:164563
Biological Process	GO:0070269	pyroptosis	ISO	J:164563
Biological Process	GO:0070269	pyroptosis	NAS	J:320796
Biological Process	GO:0070269	pyroptosis	IMP	J:189777
Biological Process	GO:0042981	regulation of apoptotic process	IEA	J:72247
Biological Process	GO:0097264	self proteolysis	ISO	J:164563
Biological Process	GO:0031098	stress-activated protein kinase signaling cascade	ISO	J:164563