GO Annotations Graph

• Symbol: Tigit
• Name: T cell immunoreceptor with Ig and ITIM domains
• ID: MGI:3642260

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:209990
Molecular Function	GO:0005102	signaling receptor binding	IBA	J:265628
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:73065
Molecular Function	GO:0005102	signaling receptor binding	IPI	J:175415
Cellular Component	GO:0009986	cell surface	ISS	J:150317
Cellular Component	GO:0009986	cell surface	IBA	J:265628
Cellular Component	GO:0009986	cell surface	ISO	J:73065
Biological Process	GO:0032695	negative regulation of interleukin-12 production	ISO	J:164563
Biological Process	GO:0032695	negative regulation of interleukin-12 production	ISS	J:150317
Biological Process	GO:0032695	negative regulation of interleukin-12 production	IBA	J:265628
Biological Process	GO:0050868	negative regulation of T cell activation	ISS	J:150317
Biological Process	GO:0050868	negative regulation of T cell activation	IBA	J:265628
Biological Process	GO:0050868	negative regulation of T cell activation	IMP	J:168902
Biological Process	GO:0050868	negative regulation of T cell activation	ISO	J:73065
Biological Process	GO:0032733	positive regulation of interleukin-10 production	ISS	J:150317
Biological Process	GO:0032733	positive regulation of interleukin-10 production	ISO	J:164563
Biological Process	GO:0032733	positive regulation of interleukin-10 production	IBA	J:265628