GO Annotations Graph

• Symbol: Apela
• Name: apelin receptor early endogenous ligand
• ID: MGI:3642370

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0031704	apelin receptor binding	ISO	J:164563
Molecular Function	GO:0005179	hormone activity	ISO	J:164563
Cellular Component	GO:0005576	extracellular region	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	IDA	J:244834
Biological Process	GO:0001525	angiogenesis	IEA	J:60000
Biological Process	GO:0060183	apelin receptor signaling pathway	ISO	J:164563
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0060976	coronary vasculature development	IMP	J:245878
Biological Process	GO:0035050	embryonic heart tube development	IMP	J:244834
Biological Process	GO:0035050	embryonic heart tube development	IMP	J:243623
Biological Process	GO:0007369	gastrulation	IEA	J:60000
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0060674	placenta blood vessel development	IMP	J:244834
Biological Process	GO:0045766	positive regulation of angiogenesis	ISO	J:164563
Biological Process	GO:1903589	positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	IMP	J:245878
Biological Process	GO:1904022	positive regulation of G protein-coupled receptor internalization	ISO	J:164563
Biological Process	GO:1901165	positive regulation of trophoblast cell migration	ISO	J:164563
Biological Process	GO:0060395	SMAD protein signal transduction	IDA	J:195995
Biological Process	GO:0001570	vasculogenesis	IMP	J:244834
Biological Process	GO:0001570	vasculogenesis	IMP	J:243623