GO Annotations Graph

• Symbol: Ces1a
• Name: carboxylesterase 1A
• ID: MGI:3648919

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0106435	carboxylesterase activity	ISO	J:164563
Molecular Function	GO:0052689	carboxylic ester hydrolase activity	IBA	J:265628
Molecular Function	GO:0004771	sterol esterase activity	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0005783	endoplasmic reticulum	IBA	J:265628
Cellular Component	GO:0005811	lipid droplet	ISO	J:164563
Cellular Component	GO:0005811	lipid droplet	IBA	J:265628
Biological Process	GO:0071397	cellular response to cholesterol	ISO	J:164563
Biological Process	GO:0071404	cellular response to low-density lipoprotein particle stimulus	ISO	J:164563
Biological Process	GO:0006695	cholesterol biosynthetic process	ISO	J:164563
Biological Process	GO:0042632	cholesterol homeostasis	ISO	J:164563
Biological Process	GO:0008203	cholesterol metabolic process	ISO	J:164563
Biological Process	GO:0030855	epithelial cell differentiation	ISO	J:164563
Biological Process	GO:0016042	lipid catabolic process	IBA	J:265628
Biological Process	GO:0051791	medium-chain fatty acid metabolic process	ISO	J:164563
Biological Process	GO:0010887	negative regulation of cholesterol storage	ISO	J:164563
Biological Process	GO:0010875	positive regulation of cholesterol efflux	ISO	J:164563
Biological Process	GO:0090205	positive regulation of cholesterol metabolic process	ISO	J:164563
Biological Process	GO:0070857	regulation of bile acid biosynthetic process	ISO	J:164563
Biological Process	GO:0120188	regulation of bile acid secretion	ISO	J:164563
Biological Process	GO:0043691	reverse cholesterol transport	ISO	J:164563