GO Annotations Graph

• Symbol: Ace
• Name: angiotensin I converting enzyme
• ID: MGI:87874

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003779	actin binding	ISO	J:164563
Molecular Function	GO:0031711	bradykinin receptor binding	ISO	J:164563
Molecular Function	GO:0005516	calmodulin binding	IEA	J:60000
Molecular Function	GO:0004180	carboxypeptidase activity	IEA	J:60000
Molecular Function	GO:0031404	chloride ion binding	ISO	J:164563
Molecular Function	GO:0004175	endopeptidase activity	ISO	J:164563
Molecular Function	GO:0008238	exopeptidase activity	ISO	J:164563
Molecular Function	GO:1901363	heterocyclic compound binding	ISO	J:155856
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0070573	metallodipeptidase activity	ISO	J:164563
Molecular Function	GO:0004222	metalloendopeptidase activity	ISO	J:164563
Molecular Function	GO:0008237	metallopeptidase activity	ISO	J:164563
Molecular Function	GO:0008237	metallopeptidase activity	IDA	J:135495
Molecular Function	GO:0008237	metallopeptidase activity	ISO	J:155856
Molecular Function	GO:0008237	metallopeptidase activity	IBA	J:265628
Molecular Function	GO:0051019	mitogen-activated protein kinase binding	ISO	J:164563
Molecular Function	GO:0031434	mitogen-activated protein kinase kinase binding	ISO	J:164563
Molecular Function	GO:0008233	peptidase activity	ISO	J:155856
Molecular Function	GO:0008233	peptidase activity	ISO	J:164563
Molecular Function	GO:0008233	peptidase activity	IMP	J:42643
Molecular Function	GO:0008241	peptidyl-dipeptidase activity	ISO	J:155856
Molecular Function	GO:0008241	peptidyl-dipeptidase activity	ISO	J:164563
Molecular Function	GO:0008241	peptidyl-dipeptidase activity	IDA	J:322689
Molecular Function	GO:0008241	peptidyl-dipeptidase activity	IDA	J:135495
Molecular Function	GO:0008241	peptidyl-dipeptidase activity	IDA	J:135495
Molecular Function	GO:0008241	peptidyl-dipeptidase activity	ISO	J:164563
Molecular Function	GO:0008241	peptidyl-dipeptidase activity	IMP	J:326019
Molecular Function	GO:0008241	peptidyl-dipeptidase activity	IDA	J:135495
Molecular Function	GO:0008241	peptidyl-dipeptidase activity	IBA	J:265628
Molecular Function	GO:0005515	protein binding	IPI	J:193640
Molecular Function	GO:0008240	tripeptidyl-peptidase activity	ISO	J:164563
Molecular Function	GO:0008270	zinc ion binding	ISO	J:164563
Cellular Component	GO:0009925	basal plasma membrane	ISO	J:155856
Cellular Component	GO:0031526	brush border membrane	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IDA	J:213091
Cellular Component	GO:0005768	endosome	ISO	J:164563
Cellular Component	GO:0009897	external side of plasma membrane	ISO	J:164563
Cellular Component	GO:0070062	extracellular exosome	ISO	J:164563
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005764	lysosome	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0005886	plasma membrane	IDA	J:213091
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0097225	sperm midpiece	ISO	J:155856
Cellular Component	GO:0031982	vesicle	ISO	J:155856
Biological Process	GO:0050435	amyloid-beta metabolic process	ISO	J:164563
Biological Process	GO:0060978	angiogenesis involved in coronary vascular morphogenesis	ISO	J:155856
Biological Process	GO:0002003	angiotensin maturation	IDA	J:135495
Biological Process	GO:0002003	angiotensin maturation	ISO	J:164563
Biological Process	GO:0002003	angiotensin maturation	IMP	J:89512
Biological Process	GO:0031100	animal organ regeneration	ISO	J:155856
Biological Process	GO:0050482	arachidonic acid secretion	ISO	J:164563
Biological Process	GO:0010815	bradykinin catabolic process	ISO	J:155856
Biological Process	GO:0010815	bradykinin catabolic process	ISO	J:164563
Biological Process	GO:0071838	cell proliferation in bone marrow	IMP	J:217279
Biological Process	GO:0042755	eating behavior	ISO	J:155856
Biological Process	GO:0009792	embryo development ending in birth or egg hatching	ISO	J:155856
Biological Process	GO:0060047	heart contraction	IMP	J:121666
Biological Process	GO:0042447	hormone catabolic process	IDA	J:135495
Biological Process	GO:0042447	hormone catabolic process	ISO	J:164563
Biological Process	GO:0042445	hormone metabolic process	ISO	J:164563
Biological Process	GO:0001822	kidney development	IMP	J:83777
Biological Process	GO:0001822	kidney development	IMP	J:89512
Biological Process	GO:0001822	kidney development	ISO	J:164563
Biological Process	GO:0001822	kidney development	IMP	J:74527
Biological Process	GO:0001822	kidney development	IMP	J:129753
Biological Process	GO:0048286	lung alveolus development	ISO	J:155856
Biological Process	GO:0008584	male gonad development	IMP	J:74527
Biological Process	GO:0008584	male gonad development	IMP	J:83777
Biological Process	GO:0090281	negative regulation of calcium ion import	ISO	J:155856
Biological Process	GO:1903597	negative regulation of gap junction assembly	IMP	J:215922
Biological Process	GO:0010629	negative regulation of gene expression	IMP	J:215922
Biological Process	GO:0046325	negative regulation of glucose import	ISO	J:155856
Biological Process	GO:0032091	negative regulation of protein binding	IMP	J:215922
Biological Process	GO:0035814	negative regulation of renal sodium excretion	ISO	J:155856
Biological Process	GO:0002446	neutrophil mediated immunity	IMP	J:140619
Biological Process	GO:0043171	peptide catabolic process	ISO	J:155856
Biological Process	GO:0043171	peptide catabolic process	ISO	J:164563
Biological Process	GO:0006518	peptide metabolic process	ISO	J:155856
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0045777	positive regulation of blood pressure	ISO	J:155856
Biological Process	GO:0050729	positive regulation of inflammatory response	ISO	J:155856
Biological Process	GO:0050769	positive regulation of neurogenesis	ISO	J:155856
Biological Process	GO:2000170	positive regulation of peptidyl-cysteine S-nitrosylation	IMP	J:215922
Biological Process	GO:1900086	positive regulation of peptidyl-tyrosine autophosphorylation	IMP	J:215922
Biological Process	GO:0032092	positive regulation of protein binding	IMP	J:215922
Biological Process	GO:0061098	positive regulation of protein tyrosine kinase activity	IMP	J:215922
Biological Process	GO:0003084	positive regulation of systemic arterial blood pressure	ISO	J:155856
Biological Process	GO:0003084	positive regulation of systemic arterial blood pressure	IBA	J:265628
Biological Process	GO:0003084	positive regulation of systemic arterial blood pressure	IMP	J:42643
Biological Process	GO:0003084	positive regulation of systemic arterial blood pressure	IMP	J:129753
Biological Process	GO:0045907	positive regulation of vasoconstriction	ISO	J:155856
Biological Process	GO:0010608	post-transcriptional regulation of gene expression	IMP	J:215922
Biological Process	GO:0006508	proteolysis	IEA	J:60000
Biological Process	GO:0006508	proteolysis	IEA	J:72247
Biological Process	GO:0060177	regulation of angiotensin metabolic process	ISO	J:164563
Biological Process	GO:0008217	regulation of blood pressure	IMP	J:89512
Biological Process	GO:0008217	regulation of blood pressure	IDA	J:135495
Biological Process	GO:0008217	regulation of blood pressure	IMP	J:83777
Biological Process	GO:0008217	regulation of blood pressure	ISO	J:155856
Biological Process	GO:0008217	regulation of blood pressure	IMP	J:74527
Biological Process	GO:1902033	regulation of hematopoietic stem cell proliferation	IMP	J:217279
Biological Process	GO:0014910	regulation of smooth muscle cell migration	ISO	J:155856
Biological Process	GO:0048167	regulation of synaptic plasticity	IDA	J:322689
Biological Process	GO:0003081	regulation of systemic arterial blood pressure by renin-angiotensin	ISO	J:164563
Biological Process	GO:0003081	regulation of systemic arterial blood pressure by renin-angiotensin	IBA	J:265628
Biological Process	GO:0032496	response to lipopolysaccharide	ISO	J:155856
Biological Process	GO:0019233	sensory perception of pain	ISO	J:155856
Biological Process	GO:0007283	spermatogenesis	IMP	J:129753
Biological Process	GO:0010814	substance P catabolic process	ISO	J:164563
Biological Process	GO:0042310	vasoconstriction	ISO	J:155856